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bombesin (7-14)

structure in first source

Also Known As:

5-Ava-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2; BBN(7-14)

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Xiaoyuan: 3 articles (10/2013 - 03/2008)
2.	Ananias, Hildo J K: 2 articles (10/2013 - 08/2011)
3.	Dierckx, Rudi A: 2 articles (10/2013 - 08/2011)
4.	Elsinga, Philip H: 2 articles (10/2013 - 08/2011)
5.	Helfrich, Wijnand: 2 articles (10/2013 - 08/2011)
6.	Wang, Fan: 2 articles (10/2013 - 08/2011)
7.	Yan, Yongjun: 2 articles (10/2013 - 08/2011)
8.	Yu, Zilin: 2 articles (10/2013 - 08/2011)
9.	de Jong, Igle J: 2 articles (10/2013 - 08/2011)
10.	Bénard, François: 1 article (06/2022)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/01/2002 - "Receptor saturation studies, carried out on the GRP receptor-expressing PC-3 human prostate cancer cell line, revealed for [99mTc(CO)(3)-N(alpha)-histidinyl acetate]bombesin(7-14) K(d) values in the subnanomolar range. " 10/01/2013 - "Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients: a first-in-man study." 08/01/2011 - "(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model." 10/01/2013 - "We used the BBN-based radiopharmaceutical (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) ((99m)Tc-HABBN) to perform a first-in-man clinical pilot study to evaluate the feasibility of (99m)Tc-HABBN SPECT/CT for detection of prostate cancer in patients. "
2.	Neoplasms (Cancer) 06/11/2022 - "Among the tested [Leu13ψThz14]Bombesin(7-14) derivatives, [68Ga]Ga-TacsBOMB5 has the highest tumor uptake and tumor-to-background contrast ratios, which is promising for clinical translation to detect GRPR-expressing tumors. " 06/11/2022 - "To lower pancreas uptake, we explored Ga-complexed TacsBOMB2, TacsBOMB3, TacsBOMB4, TacsBOMB5, and TacsBOMB6 derived from a potent GRPR antagonist sequence, [Leu13ψThz14]Bombesin(7-14), and compared their potential for cancer imaging with [68Ga]Ga-RM2. " 07/01/2002 - "We therefore conclude that [99mTc(I)-PADA-AVA]bombesin (7-14) might have promising characteristics for applications in nuclear medicine, namely for diagnosis of GRP receptor overexpressing tumors." 05/01/2002 - "Despite the weak proteolytic stability of [99mTc(CO)(3)-N(alpha)-histidinyl acetate]bombesin(7-14) in vitro, biodistribution studies, performed in PC-3 tumor-bearing mice, showed low uptake in the tumor (0.89 +/- 0.27% ID/g 30 min pi) but high uptake into the pancreas (7.11 +/- 3.93% ID/g 30 min pi), a GRP receptor-positive organ. " 03/01/2008 - "The PC-3 tumor uptake of (18)F-FB-BBN-RGD was inhibited only partially in the presence of an excess amount of unlabeled BBN(7-14) or c(RGDyK) but was blocked completely in the presence of both BBN(7-14) and c(RGDyK). "
3.	Breast Neoplasms (Breast Cancer) 01/01/2010 - "Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] conjugates for targeting gastrin-releasing peptide receptors overexpressed on breast carcinoma."

Related Drugs and Biologics

1.	Technetium (Technetium 99m)
2.	tricine
3.	Acetates (Acetic Acid Esters)
4.	Radiopharmaceuticals
5.	Bombesin Receptors (Bombesin Receptor)
6.	Peptides (Polypeptides)
7.	Bombesin
8.	(18)F-FB-BBN-RGD