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pyrazolopyridine

act as competitive antagonists of brain adenosine A1 receptors

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - pyrazolopyridine: 16
  - Pyridines: 88
    - pyrazolopyridine: 16

Experts

1.	Carrete, Alex: 1 article (10/2021)
2.	Jafarian-Tehrani, Mehrnaz: 1 article (10/2021)
3.	Meffre, Delphine: 1 article (10/2021)
4.	Padilla-Ferrer, Aïda: 1 article (10/2021)
5.	Simon, Anne: 1 article (10/2021)
6.	Bolton, Clare M: 1 article (08/2019)
7.	Boyall, Dean: 1 article (08/2019)
8.	Brenchley, Guy: 1 article (08/2019)
9.	Chiu, Peter: 1 article (08/2019)
10.	Collier, Philip N: 1 article (08/2019)

Related Diseases

1.	Neuroblastoma 03/31/2017 - "The aim of the present study is to synthesize potential neuroprotective heterocyclic compounds based on pyrazolopyridine derivatives and then to evaluate their effects in MPP+-induced neurodegeneration in human neuroblastoma cell line (SH-SY5Y cells). "
2.	Pulmonary Hypertension 11/25/2010 - "The present study investigated whether BAY 41-2272(5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine), a novel pyrazolopyridine that activates guanylyl cyclase and sensitizes the enzyme towards nitric oxide (NO), inhibits the development of pulmonary hypertension. "
3.	Asthma (Bronchial Asthma) 09/01/1986 - "From the results obtained in this study, it is considered that the pyrazolopyridine derivatives, particularly KC-404, may be promising bronchodilators for the treatment of bronchial asthma."
4.	Idiopathic Pulmonary Fibrosis 08/01/2011 - "Recently, small molecule pyrazolopyridine and triazolopyrimidine derivatives have been submitted as potent NADPH oxidase inhibitors and reported as first-in-class inhibitors for idiopathic pulmonary fibrosis and acute stroke, respectively. "
5.	Stroke (Strokes) 08/01/2011 - "Recently, small molecule pyrazolopyridine and triazolopyrimidine derivatives have been submitted as potent NADPH oxidase inhibitors and reported as first-in-class inhibitors for idiopathic pulmonary fibrosis and acute stroke, respectively. "

Related Drugs and Biologics

1.	3- (4- Amino- 5- cyclopropylpyrimidine- 2- yl)- 1- (2- fluorobenzyl)- 1H- pyrazolo(3,4- b)pyridine
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Heterocyclic Compounds (Compounds, Heterocyclic)
4.	Guanylate Cyclase (Guanylyl Cyclase)
5.	Enzymes
6.	Bronchodilator Agents (Bronchodilators)
7.	ibudilast
8.	KDU731
9.	Amyloid Precursor Protein Secretases (beta-Secretase)
10.	NADPH Oxidases (NAD(P)H oxidase)