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negative elongation factor (NELF)

a multisubunit complex; cooperates with DRB sensitivity-inducing factor (DSIF) to repress RNA polymerase II transcription elongation; has been sequenced; contains RD protein
Also Known As:
NELF; negative elongation factor A; negative elongation factor B; negative elongation factor C; negative elongation factor D; negative elongation factor E
Networked: 33 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Yamaguchi, Yuki: 7 articles (06/2009 - 05/2002)
2. Handa, Hiroshi: 7 articles (06/2009 - 05/2002)
3. Li, Rong: 5 articles (04/2014 - 09/2004)
4. Narita, Takashi: 4 articles (06/2009 - 05/2002)
5. Gilmour, David S: 3 articles (10/2011 - 01/2005)
6. Cameron, Richard S: 2 articles (05/2015 - 04/2011)
7. Kim, Hyung-Goo: 2 articles (05/2015 - 04/2011)
8. Chorich, Lynn P: 2 articles (05/2015 - 04/2011)
9. Layman, Lawrence C: 2 articles (05/2015 - 04/2011)
10. Trarbach, Ericka B: 2 articles (11/2011 - 12/2005)

Related Diseases

1. Shock
2. Breast Neoplasms (Breast Cancer)
3. Neoplasms (Cancer)
10/01/2010 - "Although the negative elongation factor complex attenuates the estrogen receptor α-mediated transcription, little is known about the relationship between TH1 and tumor progression. "
07/01/2015 - "Hypermethylation of RDBP (negative elongation factor complex member E) in metastatic tumors was further validated by bisulfite pyrosequencing [Δβmetastatic-benign = 0.29, P = 0.003; HR, 1.4; 95% confidence interval (CI), 1.1-2.0; P = 0.018] and may alter transcriptional networks involving (RERG, GPX3, and PDZK1) apoptosis, invasion, and maintenance of DNA integrity. "
04/20/2007 - "In order to identify new proteins interacting with hampin, we screened a mouse cDNA library in yeast two-hybrid system with mouse hampin as bait and found five high-confidence interactors: MYST1, TPR proteins TTC4 and KIAA0103, NOP17 (homolog of a yeast nucleolar protein), and transcription factor GC BP. Subsequently, all these proteins were used as baits in library screenings and more new interactions were found: tumor suppressor RASSF1C and spliceosome component PRP3 for KIAA0103, ring finger RNF10 for RASSF1C, and RNA polymerase II regulator NELF-C for MYST1. "
06/10/2009 - "Negative Elongation Factor (NELF) is a transcription factor discovered based on its biochemical activity to suppress transcription elongation, and has since been implicated in various diseases ranging from neurological disorders to cancer. "
05/11/2007 - "Negative elongation factor (NELF) is a four subunit transcription elongation factor that has been implicated in numerous diseases ranging from neurological disorders to cancer. "
4. Kallmann Syndrome (Kallmann's Syndrome)
5. Hypogonadism (Hypergonadotropic Hypogonadism)

Related Drugs and Biologics

1. RNA Polymerase II (RNA Polymerase B)
2. Estrogens (Estrogen)
3. Small Interfering RNA (siRNA)
4. trefoil factor
5. negative elongation factor (NELF)
6. Proteins (Proteins, Gene)
7. Gonadotropin-Releasing Hormone (GnRH)
8. DNA (Deoxyribonucleic Acid)
9. Hepatitis delta Antigens (HDAg)
10. RNA-Binding Proteins (RNA-Binding Protein)