OPEN protocol

chemotherapy protocol consisting of above compounds; used for the treatment of follicular large cell lymphoma

Also Known As:

OPEN regimen

Networked: 14 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - OPEN protocol: 14
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - OPEN protocol: 14
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - OPEN protocol: 14
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        Podophyllotoxin: 562
        Etoposide: 10706
        OPEN protocol: 14
        Anthracenes: 12
        Anthrones: 12
        Anthraquinones: 788
        Mitoxantrone: 2907
        OPEN protocol: 14
- Quinones: 434
  - Anthraquinones: 788
    - Mitoxantrone: 2907
      - OPEN protocol: 14
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - Podophyllotoxin: 562
        Etoposide: 10706
        OPEN protocol: 14
  - Anthracenes: 12
    - Anthrones: 12
      - Anthraquinones: 788
        Mitoxantrone: 2907
        OPEN protocol: 14
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienediols
        Prednisone: 12650
        OPEN protocol: 14
Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - Etoposide: 10706
      - OPEN protocol: 14
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Vinca Alkaloids: 463
        Vincristine: 9251
        OPEN protocol: 14
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        Vincristine: 9251
        OPEN protocol: 14
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        Vincristine: 9251
        OPEN protocol: 14

Experts

1.	Baker, Errol H: 3 articles (06/2014 - 04/2005)
2.	Martin, Paula I: 3 articles (06/2014 - 04/2005)
3.	Naeser, Margaret A: 3 articles (06/2014 - 04/2005)
4.	Pascual-Leone, Alvaro: 2 articles (01/2014 - 04/2005)
5.	Chiofalo, M F: 1 article (05/2020)
6.	Marín-Romero, B: 1 article (05/2020)
7.	Tirapu-Ustárroz, J: 1 article (05/2020)
8.	Frazier, Judith: 1 article (06/2014)
9.	Hamblin, Michael R: 1 article (06/2014)
10.	Knight, Jeffrey A: 1 article (06/2014)

Related Diseases

1.	Aphasia (Dysphasia) 04/01/2005 - "Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study."
2.	Stroke (Strokes) 07/01/2012 - "Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: an open protocol case series." 08/27/2001 - "We report seven patients treated with recombinant tissue plasminogen activator (rtPA) within three hours of the onset of stroke according to an open protocol following internationally accepted guidelines. "
3.	Bacteremia 02/01/1990 - "The efficacy of short-course ceftriaxone monotherapy in treatment of bacteremia was evaluated in an open protocol. "
4.	Heart Failure 12/01/2000 - "Patients with congestive heart failure: placebo controlled (n = 26) and an open protocol (n = 15). " 04/01/1999 - "Forty-eight patients with congestive heart failure were investigated: 30 patients with dilated cardiomyopathy participating in a placebo-controlled trial (15 on placebo, 15 on metoprolol), and 18 patients treated by metoprolol in an open protocol. "
5.	Ulcerative Colitis 05/01/1993 - "Ten patients with treatment-resistant left-sided ulcerative colitis were treated in an open protocol with 350 mg cyclosporine enemas nightly for 4 wk. A 12-point clinical disease activity index (DAI) score was calculated at baseline and after 4 wk. Whole blood and colonic tissue cyclosporine concentrations were determined by HPLC at the end of the study. " 08/01/1997 - "Ten non-smoking patients with mildly to moderately active left-sided ulcerative colitis unresponsive to first-line therapy were treated in an open protocol with nightly nicotine tartrate liquid enemas at a dose of 3 mg nicotine base for 1 week then 6 mg for 3 weeks. "

Related Drugs and Biologics

1.	Ceftriaxone (Ceftriaxon)
2.	Cyclosporine (Ciclosporin)
3.	Metoprolol (Toprol-XL)
4.	Antigens
5.	Tissue Plasminogen Activator (Alteplase)
6.	Nicotine

Related Therapies and Procedures

1.	Therapeutics
2.	Enema (Enemas)
3.	Lasers (Laser)
4.	Transcutaneous Electric Nerve Stimulation (TENS)
5.	Complementary Therapies (Alternative Medicine)