KF 20444

immunosuppressive agent that has been synthesized by stabilizing the three-dimensional structure of BQR with expectation of enhanced immunosuppressive activity with lesser toxicity

Also Known As:

KF20444

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        KF 20444: 1

Experts

1.	Kobayashi, K: 1 article (01/2001)
2.	Miki, I: 1 article (01/2001)
3.	Nagata, H: 1 article (01/2001)
4.	Nakajima, H: 1 article (01/2001)
5.	Nakashima, A: 1 article (01/2001)
6.	Sato, S: 1 article (01/2001)
7.	Yamaguchi, K: 1 article (01/2001)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2001 - "KF20444 is a novel immunosuppressant which inhibits DHO-DHase and its effects in CIA suggest that it could be useful in the treatment of rheumatoid arthritis."
2.	Body Weight (Weight, Body) 01/01/2001 - "The 50% effective dose (ED50) of KF20444 on arthritis score was 0.64 mg/kg. KF20444 ameliorated body weight loss associated with disease onset. "
3.	Experimental Arthritis 01/01/2001 - "Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis." 01/01/2001 - "A newly synthesized inhibitor of pyrimidine de novo biosynthesis, KF20444 (6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H-benzo [6,7] cyclohepta [1,2-b] quinoline-8-carboxylic acid), was evaluated as an inhibitor of dihydroorotate dehydrogenase (DHO-DHase) and tested in the rat collagen-induced arthritis (CIA) model. "
4.	Arthritis (Polyarthritis) 01/01/2001 - "Treatment with 3 mg/kg/day of KF20444 completely prevented the development of CIA based on reduction of the arthritis score. " 01/01/2001 - "The 50% effective dose (ED50) of KF20444 on arthritis score was 0.64 mg/kg. KF20444 ameliorated body weight loss associated with disease onset. " 01/01/2001 - "Importantly, KF20444 suppressed the development of arthritis, even when it was administered after booster immunization of collagen. "

Related Drugs and Biologics

1.	Immunosuppressive Agents (Immunosuppressants)
2.	Collagen
3.	Carboxylic Acids
4.	Dihydroorotate Dehydrogenase
5.	quinoline
6.	pyrimidine