|1.||Nakashima, A: 1 article (01/2001)|
|2.||Miki, I: 1 article (01/2001)|
|3.||Nakajima, H: 1 article (01/2001)|
|4.||Sato, S: 1 article (01/2001)|
|5.||Kobayashi, K: 1 article (01/2001)|
|6.||Nagata, H: 1 article (01/2001)|
|7.||Yamaguchi, K: 1 article (01/2001)|
|2.||Body Weight (Weight, Body)
01/01/2001 - "Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis."
01/01/2001 - "A newly synthesized inhibitor of pyrimidine de novo biosynthesis, KF20444 (6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H-benzo [6,7] cyclohepta [1,2-b] quinoline-8-carboxylic acid), was evaluated as an inhibitor of dihydroorotate dehydrogenase (DHO-DHase) and tested in the rat collagen-induced arthritis (CIA) model. "
01/01/2001 - "Treatment with 3 mg/kg/day of KF20444 completely prevented the development of CIA based on reduction of the arthritis score. "
01/01/2001 - "The 50% effective dose (ED50) of KF20444 on arthritis score was 0.64 mg/kg. KF20444 ameliorated body weight loss associated with disease onset. "
01/01/2001 - "Importantly, KF20444 suppressed the development of arthritis, even when it was administered after booster immunization of collagen. "