|1.||Horwitz, Jerome P: 5 articles (01/2007 - 02/2002)|
|2.||Polin, Lisa: 5 articles (01/2007 - 02/2002)|
|3.||Hazeldine, Stuart T: 4 articles (01/2007 - 02/2002)|
|4.||Corbett, Thomas H: 3 articles (06/2005 - 02/2002)|
|5.||Kushner, Juiwanna: 3 articles (06/2005 - 02/2002)|
|6.||White, Kathryn: 3 articles (06/2005 - 02/2002)|
|7.||Mohammad, Ramzi M: 3 articles (11/2003 - 12/2002)|
|8.||Al-Katib, Ayad M: 3 articles (11/2003 - 12/2002)|
|9.||Mensah-Osman, Edith J: 3 articles (11/2003 - 12/2002)|
|10.||Chan, Kenneth K: 3 articles (06/2003 - 03/2002)|
04/01/2002 - "Previous studies have indicated that XK469 is an antiproliferative agent with a low cytotoxic effect in human H116 tumor cells. "
01/01/2011 - "The quinoxaline anti-tumor agent (R+)XK469 mediates its effects by topoisomerase IIB inhibition. "
07/04/2002 - "These results indicate that the induction of apoptosis by XK469 may account for its anti-tumor activity and such activity is required for the activation of the mitochondrial pathway. "
07/04/2002 - "Here we investigate the ability of XK469 to induce apoptosis of human cancer cells. "
07/04/2002 - "XK469, a synthetic quinoxaline phenoxypropionic acid derivative, has been found to have selective activity against a broad panel of solid tumors including several drug-resistant cell lines and has been approved for phase I clinical evaluation. "
01/01/2011 - "This report describes a 14-year old with relapsed neuroblastoma who experienced disease stabilization for 14 months while receiving (R+)XK469 monotherapy. "
01/01/2011 - "These preclinical results, coupled with the favorable clinical response, demonstrate that (R+)XK469 and similar anti-tumor agents may be effective in the treatment of high-risk neuroblastoma and warrant further testing."
01/01/2011 - "The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth."
01/01/2011 - "(R+)XK469 inhibited proliferation, caused G(2) cell cycle arrest of neuroblastoma cells in vitro, and inhibited growth of neuroblastoma xenograft tumors. "
|3.||Waldenstrom Macroglobulinemia (Macroglobulinemia)
12/01/2003 - "We have previously reported that XK469 inhibited topoisomerase (topo) IIbeta, in Waldenstrom's macroglobulinemia cell line (WSU-WM) however the inhibition alone is not sufficient to induce apoptosis. "
12/01/2003 - "XK469, a topo IIbeta inhibitor, induces apoptosis in Waldenstrom's macroglobulinemia through multiple pathways."
12/01/2002 - "Using the Waldenstrom's macroglobulinemia (WM) cell line WSU-WM, we show that XK469 induced the expression of Topo IIalpha protein by 24 h compared with control. "
12/01/2002 - "2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model."
12/01/2002 - "In this study, we investigated Topo IIbeta as a target for 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469), a novel synthetic quinoxaline phenoxypropionic acid derivative, in a Waldenstrom's macroglobulinemia (WM) model. "
04/01/2002 - "Our findings suggest that the antiproliferative effect of XK469 is mediated by inhibiting the MEK/MAPK signaling pathways in U-937 human leukemia cells."
04/01/2002 - "The antiproliferative activity of XK469 was tested using human U-937 leukemia cells in culture. "
10/12/1999 - "Preferential targeting of topoisomerase IIbeta may explain the solid tumor selectivity of XK469 and its analogs because solid tumors, unlike leukemias, often have large populations of cells in the G(1)/G(0) phases of the cell cycle in which topoisomerase IIbeta is high whereas topoisomerase IIalpha, the primary target of many leukemia selective drugs, is low."
02/01/2002 - "This leukemia subline (L1210/XK469) had reduced sensitivity to VP-16 (with a 4.0 log kill in i.v. implanted L1210/XK469 compared to an 8.0 log kill against i.v. implanted L1210/0). "
01/01/1998 - "In vitro, XK469 demonstrated selective cytotoxicity for several murine solid tumors including colorectal and mammary adenocarcinoma cell lines, when compared to both leukemia and normal epithelial cells. "
07/26/2001 - "Using murine leukemia L1210 cells in culture, we found the chiral R(+) form of XK469 to be substantially more cytotoxic than the S(-) form, while the herbicide analog 'Assure' was essentially inactive. "
01/01/2007 - "The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80."
|1.||propionic acid (potassium propionate)
|2.||trioctyl phosphine oxide (TOPO)
|3.||Etoposide (VP 16)
|5.||DNA (Deoxyribonucleic Acid)
|7.||Cytochromes c (Cytochrome c)
|9.||Succinic Acid (Succinate)
|1.||Heterologous Transplantation (Xenotransplantation)