HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

bgugaine

a pyrrolidine alkaloid from tuber, Arisarum vulgare that is a strong hepatoxin in liver cell cultures

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - bgugaine: 2
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - bgugaine: 2

Experts

1.	Aziz, Mohammed: 1 article (01/2009)
2.	Benamar, Malika: 1 article (01/2009)
3.	Bouabdallah, Ibrahim: 1 article (01/2009)
4.	Melhaoui, Ahmed: 1 article (01/2009)
5.	Zyad, Abdelmajid: 1 article (01/2009)

Related Diseases

1.	Mastocytoma 01/01/2009 - "(Araceae), and its isomer S-bgugaine, obtained by an asymmetric synthesis, were examined for their cytotoxic activities on two cancerous cellular lines: the murine mastocytoma cell line P815 and the human laryngeal carcinoma cell line Hep. " 01/01/2009 - "The concentrations required to induce 50% of lysis (IC(50)) for R-bgugaine and S-bgugaine alkaloids were determined, and are 10 and 5 microg mL(-1), and 5 and 100 microg mL(-1), respectively, for the mastocytoma P815 and carcinoma Hep, compared with those of Adriamycine (5 microg mL(-1) for P815 cell line and 5 microg mL(-1) for Hep cell line), taken as positive controls."
2.	Hepatoblastoma 02/22/1999 - "Toxicity of bgugaine, a pyrrolidine alkaloid extracted from the tubers of Arisarum vulgare, was studied in three different liver cell culture models: (1) the rat hepatocyte primary culture; (2) a liver epithelial cell line; and (3) the human hepatoblastoma cell line HepG2. "
3.	Carcinoma (Carcinomatosis) 01/01/2009 - "(Araceae), and its isomer S-bgugaine, obtained by an asymmetric synthesis, were examined for their cytotoxic activities on two cancerous cellular lines: the murine mastocytoma cell line P815 and the human laryngeal carcinoma cell line Hep. " 01/01/2009 - "The concentrations required to induce 50% of lysis (IC(50)) for R-bgugaine and S-bgugaine alkaloids were determined, and are 10 and 5 microg mL(-1), and 5 and 100 microg mL(-1), respectively, for the mastocytoma P815 and carcinoma Hep, compared with those of Adriamycine (5 microg mL(-1) for P815 cell line and 5 microg mL(-1) for Hep cell line), taken as positive controls."

Related Drugs and Biologics

1.	Alkaloids
2.	pyrrolidine