08/01/1998 - "While IPM demonstrated greater efficacy than MK-826 against Enterobacter cloacae (50% effective doses [ED50s] of 0.062 and 0.227 mg/kg, respectively) and Pseudomonas aeruginosa (ED50s of 0.142 and 3.0 mg/kg, respectively) systemic infections, MK-826 was 8- to 350-fold more efficacious than IPM against all other gram-negative organisms in this infection model. "
08/01/1998 - "Similar activities of IPM and MK-826 were observed in a gram-positive bacterial murine systemic infection model. "
08/01/1998 - "In a localized murine thigh infection model, MK-826 and IPM were superior to a variety of beta-lactam antibiotics in reduction of Staphylococcus aureus CFU compared with results from nontreated controls (eliminating >/=4 log10 CFU). "
|2.||Body Weight (Weight, Body)
|2.||Anti-Bacterial Agents (Antibiotics)