MK 826

a carbapenem antibiotic, arising from concentration-dependent plasma protein binding in rats and monkeys; structure in first source

Also Known As:

3-((2-(((3-carboxyphenyl)amino)carbonyl)pyrrolidin-4-yl)thio)-4-methyl-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-en-2-carboxylic acid monosodium salt; MK-826

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - beta-Lactams: 2386
      - Carbapenems: 4837
        MK 826: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - beta-Lactams: 2386
      - Carbapenems: 4837
        MK 826: 1

Related Diseases

1.	Infections 08/01/1998 - "While IPM demonstrated greater efficacy than MK-826 against Enterobacter cloacae (50% effective doses [ED50s] of 0.062 and 0.227 mg/kg, respectively) and Pseudomonas aeruginosa (ED50s of 0.142 and 3.0 mg/kg, respectively) systemic infections, MK-826 was 8- to 350-fold more efficacious than IPM against all other gram-negative organisms in this infection model. " 08/01/1998 - "Similar activities of IPM and MK-826 were observed in a gram-positive bacterial murine systemic infection model. " 08/01/1998 - "In a localized murine thigh infection model, MK-826 and IPM were superior to a variety of beta-lactam antibiotics in reduction of Staphylococcus aureus CFU compared with results from nontreated controls (eliminating >/=4 log10 CFU). "
2.	Body Weight (Weight, Body) 08/01/1998 - "The distribution in tissue and pharmacokinetic properties of MK-826 and ceftriaxone (CTRX) were also evaluated in CD-1 mice following a single intraperitoneal dose (10 mg/kg of body weight). "

Related Drugs and Biologics

1.	Ceftriaxone (Ceftriaxon)
2.	beta Lactam Antibiotics