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LU 73068

a non-NMDA and glycine/NMDA receptor antagonist; structure in first source

Also Known As:

4,5-dihydro-1-methyl-4-oxo-7-trifluoromethylimidazo(1,2-a)quinoxaline-2-carboxylic acid; LU-73068

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - LU 73068: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - LU 73068: 1

Related Diseases

1.	Seizures (Absence Seizure) 11/01/1998 - "When rats were stimulated with a current 20% above the individual control ADT, LU 73068 completely blocked seizures with an ED50 of 4.9 mg kg(-1). " 11/01/1998 - "In the rat amygdala kindling model of temporal lobe epilepsy, LU 73068 dose-dependently increased the focal seizure threshold (afterdischarge threshold, ADT). "
2.	Temporal Lobe Epilepsy 11/01/1998 - "In the rat amygdala kindling model of temporal lobe epilepsy, LU 73068 dose-dependently increased the focal seizure threshold (afterdischarge threshold, ADT). "
3.	Epilepsy (Aura) 11/01/1998 - "LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Glycine (Aminoacetic Acid)
4.	L 701324
5.	2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)