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1- ((3- (2- hydroxyethoxy)- 1- isopropoxy)propyl)- 5- fluorouracil

prodrug of acrolein; structure in first source

Also Known As:

GR 891; GR-891

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        Fluorouracil: 26711
        1-((3-(2-hydroxyethoxy)-1-isopropoxy)propyl)-5-fluorouracil: 1

Related Diseases

1.

Rhabdomyosarcoma

02/01/1999 - "New acyclonucleoside-like compounds such as GR-891 have important potential advantages over 5-fluorouracil because of their lower toxicity and their ability to induce myogenic differentiation in rhabdomyosarcoma cells. "
02/01/1999 - "Both GR-891 and 5-fluorouracil caused time- and dose-dependent growth inhibition in vitro; however, GR-891 showed no cytotoxicity at low doses (22.5 micromol l(-1) and 45 micromol l(-1)) and induced terminal myogenic differentiation in RD cells (a rhabdomyosarcoma cell line) treated for 6 days. "
02/01/1999 - "GR-891: a novel 5-fluorouracil acyclonucleoside prodrug for differentiation therapy in rhabdomyosarcoma cells."

Related Drugs and Biologics

1.	Prodrugs
2.	Fluorouracil (Carac)

Related Therapies and Procedures

1.	Therapeutics