apicularen A

11/01/2007 - "In in vivo studies, apicularen A reduced tumor volume by approximately 72% at the end of a 15-day treatment. "
01/22/2014 - "These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer."
11/01/2007 - "Apicularen A has been shown to cause growth inhibition and apoptosis in several cancer cell lines. "
12/15/2003 - "The developed synthetic technology was applied to the construction of a series of apicularen A analogues whose biological evaluation established a set of structure-activity relationships in this new area of potential importance in cancer chemotherapy."
01/22/2014 - "Apicularen A induces cytotoxicity in tumor cells through disrupting microtubule networks by tubulin down-regulation. "

11/01/2007 - "In this study, we investigated the molecular mechanisms of apicularen A-induced cell death in HM7 human colon cancer cells in vitro and anticancer activity in vivo. "
05/10/2013 - "In this study, we synthesized apicularen A acetate, an acetyl derivative of apicularen A, and investigated its antitumor effect and mechanism in HM7 colon cancer cells. "
05/10/2013 - "Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells."
11/01/2007 - "Apicularen A induces cell death through Fas ligand up-regulation and microtubule disruption by tubulin down-regulation in HM7 human colon cancer cells."

04/01/2005 - "Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60."
04/01/2005 - "Apicularen A, a macrolide isolated from the myxobacterial genus Chondromyces, suppressed the proliferation of human promyelocytic leukemia cells (HL-60 cells), increased the release of lactate dehydrogenase and induced condensation and fragmentation of chromatin at 1 to 100 nM. In addition, it induced the DNA fragmentation, increased the percentage of annexin V-stained cells, and cleaved poly(ADP-ribose) polymerase (PARP), a substrate of caspase. "

02/01/2007 - "Inhibition of bone resorption in cultures of mouse calvariae by apicularen A."
02/01/2007 - "Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1beta more potently than apicularen B, probably due to inhibition of the V-ATPase."
02/01/2007 - "The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. "
02/01/2007 - "Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1beta (IL-1beta) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. "