|1.||Kim, Jong-Seok: 3 articles (01/2014 - 11/2007)|
|2.||Song, Kyoung-Sub: 3 articles (01/2014 - 11/2007)|
|3.||Yun, Eun-Jin: 3 articles (01/2014 - 11/2007)|
|4.||Hwang, Byung-Doo: 3 articles (01/2014 - 11/2007)|
|5.||Park, Ji-Hoon: 3 articles (01/2014 - 11/2007)|
|6.||Park, Jong-Il: 3 articles (01/2014 - 11/2007)|
|7.||Seo, Kang-Sik: 3 articles (01/2014 - 11/2007)|
|8.||Yoon, Wan-Hee: 3 articles (01/2014 - 11/2007)|
|9.||Lim, Kyu: 3 articles (01/2014 - 11/2007)|
|10.||Kweon, Gi Ryang: 2 articles (01/2014 - 05/2013)|
11/01/2007 - "In in vivo studies, apicularen A reduced tumor volume by approximately 72% at the end of a 15-day treatment. "
01/01/2014 - "These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer."
05/10/2013 - "Apicularen A is a novel antitumor agent and strongly induces death in tumor cells. "
01/06/2012 - "Cytostatic activities of (-)-apicularen A and the three analogues for three different cancer cell lines are described."
11/01/2007 - "Apicularen A has been shown to cause growth inhibition and apoptosis in several cancer cell lines. "
|2.||Colonic Neoplasms (Colon Cancer)
05/10/2013 - "In this study, we synthesized apicularen A acetate, an acetyl derivative of apicularen A, and investigated its antitumor effect and mechanism in HM7 colon cancer cells. "
11/01/2007 - "In this study, we investigated the molecular mechanisms of apicularen A-induced cell death in HM7 human colon cancer cells in vitro and anticancer activity in vivo. "
05/10/2013 - "Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells."
11/01/2007 - "Apicularen A induces cell death through Fas ligand up-regulation and microtubule disruption by tubulin down-regulation in HM7 human colon cancer cells."
04/01/2005 - "Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60."
04/01/2005 - "Apicularen A, a macrolide isolated from the myxobacterial genus Chondromyces, suppressed the proliferation of human promyelocytic leukemia cells (HL-60 cells), increased the release of lactate dehydrogenase and induced condensation and fragmentation of chromatin at 1 to 100 nM. In addition, it induced the DNA fragmentation, increased the percentage of annexin V-stained cells, and cleaved poly(ADP-ribose) polymerase (PARP), a substrate of caspase. "
02/01/2007 - "Inhibition of bone resorption in cultures of mouse calvariae by apicularen A."
02/01/2007 - "The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. "
02/01/2007 - "Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1beta more potently than apicularen B, probably due to inhibition of the V-ATPase."
02/01/2007 - "Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1beta (IL-1beta) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. "
|3.||Interleukin-1beta (Interleukin 1 beta)
|4.||Fas Ligand Protein (Fas Ligand)
|6.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|7.||Parathyroid Hormone (Parathormone)
|8.||L-Lactate Dehydrogenase (Lactate Dehydrogenase)
|9.||Dihydrotachysterol (AT 10)
|1.||Drug Therapy (Chemotherapy)