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plasmalogen-selective phospholipase A2
catalyzes hydrolysis of arachidonic acid from sn-2 position of plasmalogen
Also Known As:
PS-PLA2; Pls-PLA(2); Pls-PLA2
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Esterases: 1574
Carboxylic Ester Hydrolases: 62
Phospholipases: 2589
Phospholipases A: 58
Phospholipases A2: 2075
plasmalogen-selective phospholipase A2: 4
Related Diseases
1.
Neurodegenerative Diseases (Neurodegenerative Disease)
09/01/1995 - "
Several lines of evidence indicate that the breakdown of plasmalogens in neural membranes during neurodegenerative diseases is a receptor-mediated process catalyzed by a plasmalogen-selective phospholipase A2.
"
2.
Myocardial Ischemia (Ischemic Heart Diseases)
07/01/1991 - "
Activation of membrane-associated plasmalogen-selective phospholipase A2 after 5 min of myocardial ischemia was rapidly reversible during reperfusion of ischemic tissue.
"
07/01/1991 - "
Collectively, these results identify dynamic alterations in calcium-independent plasmalogen-selective phospholipase A2 activity during myocardial ischemia which precede irreversible cellular injury and demonstrate that activation of plasmalogen-selective phospholipase A2 is amongst the earliest biochemical alterations in ischemic myocardium.
"
07/01/1991 - "
The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia.
"
3.
Wounds and Injuries (Trauma)
01/01/1996 - "
Plasmalogen-selective phospholipase A2 plays an important role in the release of free fatty acids and platelet-activating factor during trauma.
"
4.
Ischemia
07/01/1991 - "
We now report that membrane-associated calcium-independent plasmalogen-selective phospholipase A2 activity increased over 400% during 2 min of global ischemia (P less than 0.01), was near maximally activated (greater than 10-fold) after only 5 min of ischemia, and remained activated throughout the entire ischemic interval examined (2-60 min).
"
5.
Alzheimer Disease (Alzheimer's Disease)
05/01/1998 - "
Plasmalogen-selective phospholipase A2 and its involvement in Alzheimer's disease.
"
Related Drugs and Biologics
1.
Platelet Activating Factor
2.
Plasmalogens
3.
Nonesterified Fatty Acids (NEFA)
4.
Calcium