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183C91

active metabolite of zolmitriptan

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - 183C91: 3

Related Diseases

1.

Migraine Disorders (Migraine)

01/01/1999 - "This open-label, parallel-group study assessed pharmacokinetics and tolerability of zolmitriptan, a 5-HT1B/1D agonist for the acute treatment of migraine, and its active metabolite, 183C91, in adolescents compared with adults. "
10/01/1997 - "This suggests that MAO-A is involved in the metabolism of 183C91 and it may be prudent to limit the daily zolmitriptan dose in migraine patients maintained on a MAO-A inhibitor. "
01/01/1998 - "The increased exposure to zolmitriptan and 183C91 by cimetidine indicated that a reduction in the total daily recommended dose of zolmitriptan may be necessary when treating migraine patients who are taking nonspecific cytochrome P450 inhibitors or specific cytochrome 1A2 inhibitors."

Related Drugs and Biologics

1.	zolmitriptan (Zomig)
2.	Monoamine Oxidase (MAO)
3.	Cytochromes
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Cimetidine (Biomet)