|1.||Demangel, Caroline: 10 articles (05/2015 - 08/2005)|
|2.||Small, Pamela L C: 8 articles (08/2012 - 02/2004)|
|3.||Guenin-Macé, Laure: 7 articles (05/2015 - 02/2010)|
|4.||Fraga, Alexandra G: 6 articles (08/2014 - 02/2007)|
|5.||Pedrosa, Jorge: 6 articles (08/2014 - 02/2007)|
|6.||Portaels, Françoise: 6 articles (01/2012 - 02/2007)|
|7.||Wansbrough-Jones, Mark: 5 articles (11/2015 - 06/2006)|
|8.||Stinear, Timothy P: 5 articles (01/2014 - 02/2004)|
|9.||Torrado, Egídio: 5 articles (01/2012 - 02/2007)|
|10.||Martins, Teresa G: 4 articles (08/2014 - 01/2010)|
07/01/2011 - "Notably, we found mycolactone in ulcer exudates harvested at the end of antibiotic therapy, suggesting that the toxin is eliminated by BU patients at a slow rate. "
07/01/2011 - "Our study provides the proof of concept that assays based on mycolactone detection in serum and ulcer exudates can form the basis of BU diagnostic tests. "
09/11/2014 - "Mycolactone is a complex macrolide toxin produced by Mycobacterium ulcerans, the causative agent of skin lesions called Buruli ulcers. "
01/01/2014 - "Baseline concentration of mycolactone measured by mass spectrometry predicted time to complete healing of small nodules and ulcers. "
04/01/2013 - "Mycolactone is a diffusible lipid secreted by the human pathogen Mycobacterium ulcerans, which induces the formation of open skin lesions referred to as Buruli ulcers. "
01/01/2015 - "ulcerans infection causes systemic perturbations in the serum metabolome that can be ascribed to mycolactone. "
01/01/2013 - "ulcerans infection where the time of infection and development of lesions can be followed in a controlled manner before and after antibiotic treatment, we have evaluated the progress of infection by assessing bacterial numbers, mycolactone production, the immune response, and lesion histopathology at regular intervals after infection and after antibiotic therapy. "
01/15/2010 - "IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone."
01/01/2008 - "No evidence that mycolactone circulated in blood serum during infection could be demonstrated. "
06/11/2007 - "In accordance with the histopathological features of BUs, our results suggest that bacterial production of mycolactone may limit both the initiation of primary immune responses and the recruitment of inflammatory cells to the infection site. "
05/01/2008 - "Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study."
11/01/2015 - "We evaluated fluorescent thin layer chromatography (f-TLC) for detection of mycolactone in the laboratory using samples from patients with Buruli ulcer and patients with similar lesions that gave a negative result on PCR for the IS2404 repeat sequence of M. "
02/01/2014 - "Mycolactone is a polyketide macrolide lipid-like secondary metabolite synthesized by Mycobacterium ulcerans, the causative agent of BU (Buruli ulcer), and is the only virulence factor for this pathogen identified to date. "
02/01/2014 - "Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer."
01/01/2014 - "We sought to measure the concentration of mycolactone within lesions of patients with Buruli ulcer before, during and after antibiotic treatment to evaluate its association with the clinical and bacteriological response to therapy. "
02/01/2011 - "This study suggests that mycolactone directly damages nerves and is responsible for the absence of pain characteristic of Buruli ulcer. "
05/01/2008 - "Our present study suggests that mycolactone directly damages nerves and is responsible for the absence of pain characteristic of Buruli ulcer. "
02/01/2010 - "Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of a necrotizing skin disease referred to as Buruli ulcer. "
01/01/2010 - "Buruli ulcer is caused by Mycobacterium ulcerans which produces an outstanding immunosuppressive toxin mycolactone that induces an ulcerative, necrotic skin disease. "
06/01/2008 - "Mycolactone is a polyketide natural product secreted by Mycobacterium ulcerans, the organism responsible for the tropical skin disease Buruli ulcer. "
05/01/2008 - "Buruli ulcer is a chronic skin disease caused by Mycobacterium ulcerans, which produces a toxic lipid mycolactone. "
06/11/2007 - "Mycolactone is a polyketide toxin produced by Mycobacterium ulcerans (Mu), the causative agent of the skin disease Buruli ulcer (BU). "
|1.||Secretory Immunoglobulin A (SIgA)
|3.||Proteins (Proteins, Gene)
|6.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|7.||Interferon-gamma (Interferon, gamma)
|8.||Insulin-Like Growth Factor I (IGF-1)
|1.||Drug Therapy (Chemotherapy)