PERK kinase

involved in signalling pathway that attenuates protein translation in response to endoplasmic reticulum stress; amino acid sequence in first source; RefSeq NM_010121 (mouse), NM_031599 (rat); see also EIF2AK3 protein, human

Also Known As:

DmPEK protein; EIF2-like protein, Drosophila; Eif2ak3 protein, mouse; Eif2ak3 protein, rat; PKR-like ER protein kinase; PRK-like ER kinase; Pek protein, Drosophila; Pek protein, rat; Perk protein, Drosophila; Perk protein, rat; eukaryotic translation initiation factor 2 alpha kinase 3, mouse; eukaryotic translation initiation factor 2 alpha kinase 3, rat; perk protein, mouse; protein kinase R-like endoplasmic reticulum kinase, mouse

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Diehl, J Alan: 2 articles (10/2016 - 01/2015)
2.	Chang, Kaihui: 1 article (06/2022)
3.	Ding, Yonghe: 1 article (06/2022)
4.	Du, Ke: 1 article (06/2022)
5.	Ma, Haiying: 1 article (06/2022)
6.	Niu, Yujuan: 1 article (06/2022)
7.	Li, Xuejun: 1 article (10/2019)
8.	Liu, Suhuan: 1 article (10/2019)
9.	Tong, Fei: 1 article (10/2019)
10.	Yan, Bing: 1 article (10/2019)

Related Diseases

1.	Neoplasms (Cancer) 03/10/2016 - "Tumor progression and the different faces of the PERK kinase." 10/01/2016 - "Herein, we discuss how PERK kinase engages in tumor initiation, transformation, adaption microenvironmental stress, chemoresistance and potential opportunities, and potential opportunities for PERK targeted therapy. " 05/01/2016 - "Our results demonstrated that insulin resistance in HepG2 cells promoted a protective unfolded protein response and upregulated the expression of ER chaperone protein GRP78, which resulted in the phosphorylation of PERK kinase to activate the PERK-mediated ER stress signal transduction pathway and the upregulation of Bcl-2 and P-gp, leading to the inhibition of the caspase-3-dependent apoptosis pathway and to the survival of liver tumor cells."
2.	Virus Diseases (Viral Diseases) 01/01/2023 - "Genomic expression analyses revealed a significant effect on host-cell innate immunity, revealing activation of the integrated stress response via PERK kinase upregulation, phosphorylation of eukaryotic initiation factor 2α (eIF2α) and type I IFN, as factors potentiating multiple host-defense mechanisms against viral infection. " 05/24/2002 - "Three stresses were studied that cause the phosphorylation of the translation initiation factor, eIF2alpha, by activating specific kinases: (i) amino acid starvation, which activates GCN2; (ii) endoplasmic reticulum (ER) stress, which activates PKR-like ER kinase, PERK kinase; and (iii) double-stranded RNA, which activates double-stranded RNA-dependent protein kinase (PKR) by mimicking viral infection. "
3.	Wounds and Injuries (Trauma) 10/01/2019 - "Blood and myocardial tissues were collected, myocardial pathological injuries were investigated, serum creatine kinase-MB (CK-MB) and cardiac troponin T (cTnT) levels were measured, left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), maximum rate of left ventricular pressure rise (+dp/dtmax) and maximum rate of left ventricular pressure drop (-dp/dtmax) were evaluated, reactive oxygen species (ROS) and caspase-3 levels were observed, ΔΨm level and ROS expression were measured, and activated transcript factor 6 (ATF6), receptor for activated C kinase 1 (RACK1), PRK-like ER kinase (PERK), glucose regulated protein 78 (GRP78) and peroxisome proliferator-activated receptor γ co-activator 1-α (PGC-1α) expressions were assessed. "
4.	Starvation 05/24/2002 - "Three stresses were studied that cause the phosphorylation of the translation initiation factor, eIF2alpha, by activating specific kinases: (i) amino acid starvation, which activates GCN2; (ii) endoplasmic reticulum (ER) stress, which activates PKR-like ER kinase, PERK kinase; and (iii) double-stranded RNA, which activates double-stranded RNA-dependent protein kinase (PKR) by mimicking viral infection. "
5.	Insulin Resistance 05/01/2016 - "Our results demonstrated that insulin resistance in HepG2 cells promoted a protective unfolded protein response and upregulated the expression of ER chaperone protein GRP78, which resulted in the phosphorylation of PERK kinase to activate the PERK-mediated ER stress signal transduction pathway and the upregulation of Bcl-2 and P-gp, leading to the inhibition of the caspase-3-dependent apoptosis pathway and to the survival of liver tumor cells."

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Proteins (Proteins, Gene)
3.	Peptide Initiation Factors (Initiation Factor)
4.	Endoplasmic Reticulum Chaperone BiP
5.	Caspase 3 (Caspase-3)
6.	MB Form Creatine Kinase
7.	Peroxisome Proliferator-Activated Receptors (PPAR)
8.	Troponin T (Troponin T1)
9.	eIF-2 Kinase (eIF 2 Kinase)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Therapeutics