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D 22888
a PDE4 inhibitor; structure in first source
Also Known As:
1-ethyl-8-methoxy-3-methyl-5-propylimidazo(1,5-a)pyrido(3,2-e)pyrazinone; D-22888
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
D 22888: 1
Pyrazines: 150
D 22888: 1
Related Diseases
1.
Pulmonary Eosinophilia (Eosinophilic Pneumonia)
02/01/1998 - "
Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs.
"
2.
Eosinophilia
02/01/1998 - "
The actions of a novel selective inhibitor of type 4 cyclic nucleotide phosphodiesterase (PDE4), D-22888, on human airway smooth muscle tone and human eosinophil respiratory burst in vitro and bronchoalveolar eosinophilia in allergen-challenged sensitized guinea pigs in vivo were assessed.
"
02/01/1998 - "
Chronic twice-daily oral dosing with D-22888 for three days caused inhibition of 24 h post-challenge BAL eosinophilia, amounting to 88% at 30 mg/kg. These in vivo actions were comparable with those achieved with other selective PDE4 inhibitors and with the corticosteroid, dexamethasone.
"
3.
Asthma (Bronchial Asthma)
02/01/1998 - "
We conclude that D-22888 exerts actions on airway smooth muscle and eosinophil recruitment and activation that suggest that D-22888 may be a promising new drug for use in the treatment of allergic obstructive airways>> diseases such as bronchial asthma.
"
Related Drugs and Biologics
1.
Phosphodiesterase 4 Inhibitors
2.
Type 4 Cyclic Nucleotide Phosphodiesterases
3.
Dexamethasone (Maxidex)
4.
Allergens
5.
Adrenal Cortex Hormones (Corticosteroids)