DNA polymerase alpha-primase

involved in coordinating DNA replication, DNA repair, & cell cycle checkpoints; also an essential factor in initiation & elongation of SV40 DNA replication; composed of four subunits, p180 (polymerase activity), p68 (B subunit), and p58 & p48 (together constitute primase activiity)

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hinds, Philip: 1 article (01/2004)
2.	Hu, Guo-Fu: 1 article (01/2004)
3.	Hu, Miaofen G: 1 article (01/2004)
4.	Kim, Yong: 1 article (01/2004)
5.	McBride, Jim: 1 article (01/2004)
6.	Tsuji, Takanori: 1 article (01/2004)
7.	Wong, David T W: 1 article (01/2004)
8.	Dai, J C: 1 article (08/2001)
9.	Flohr, C: 1 article (08/2001)
10.	Hunzicker, A: 1 article (08/2001)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1989 - "DNA Polymerase-alpha/primase complexes have been isolated from human neuroblastoma IMR-32, embryonic chicken brains (ECB) and rat prostate tumor PA-3 cells. " 12/01/1998 - "Physical interactions of simian virus 40 (SV40) large tumor (T) antigen with cellular DNA polymerase alpha-primase (Pol/Prim) and replication protein A (RPA) appear to be responsible for multiple functional interactions among these proteins that are required for initiation of viral DNA replication at the origin, as well as during lagging-strand synthesis. "
2.	Infections 11/01/1993 - "We propose that a novel 12S DNA polymerase alpha-primase complex prone to disruption by salt is induced by MVM infection and that the DNA primase component of the complex is modified." 05/30/1989 - "The ratio of primase-free DNA polymerase alpha to the DNA polymerase alpha-primase complex increased from 1.5 to greater than 100 during the course of infection, and free primase was produced during the MVM replicative cycle."
3.	Papilloma (Papillomatosis) 08/30/1994 - "The role of the cellular DNA polymerase alpha-primase holoenzyme was probed by using soluble extracts from rodent cells that replicate bovine papilloma virus 1 and human papilloma virus 6b DNA in the presence of the viral E1 helicase and the E2 transcription factor. "
4.	Neuroblastoma 01/01/1989 - "DNA Polymerase-alpha/primase complexes have been isolated from human neuroblastoma IMR-32, embryonic chicken brains (ECB) and rat prostate tumor PA-3 cells. "
5.	Experimental Liver Neoplasms 08/01/2001 - "A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex." 08/01/2001 - "Thus, the amino acid change found in subunit B appears to result in a conformational change of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells. " 08/01/2001 - "To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences of the four subunits of DNA polymerase alpha-primase from both highly malignant Novikoff hepatoma cells and regenerating normal rat liver and compared physicochemical and catalytic properties of the DNA polymerase alpha-primase complexes purified from both sources. "

Related Drugs and Biologics

1.	DNA Primase (Primase)
2.	Replication Protein A
3.	Cyclin-Dependent Kinase 2
4.	Holoenzymes
5.	Complementary DNA (cDNA)
6.	Transcription Factors (Transcription Factor)
7.	Salts
8.	Proteins (Proteins, Gene)
9.	Viral DNA
10.	DNA Polymerase I (Klenow Fragment)