ORF 50 transactivator

homologous to Epstein-Barr virus R protein; isolated from Kaposi's sarcoma-associated herpesvirus; has been sequenced; do not confuse with orf50 protein

Also Known As:

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	DeMaster, Laura K: 1 article (01/2014)
2.	Rose, Timothy M: 1 article (01/2014)
3.	Bechtel, Jill T: 1 article (06/2003)
4.	Ganem, Don: 1 article (06/2003)
5.	Hvidding, Joshua: 1 article (06/2003)
6.	Liang, Yuying: 1 article (06/2003)
7.	Deng, Hongyu: 1 article (06/2002)
8.	Smith, Rita M: 1 article (06/2002)
9.	Spearman, Paul: 1 article (06/2002)
10.	Sun, Ren: 1 article (06/2002)

Related Diseases

1.	Infections 01/05/2014 - "Our studies suggest that RRV lacks the Rta-inducible LANA promoter that is responsible for LANA inhibition of the KSHV Rta promoter and induction of latency during KSHV infection. " 01/01/2022 - "Based on our results we propose that RYBP uses a PRC1-independent mechanism to block KSHV RTA expression thereby promoting the establishment of KSHV latency following de novo infection." 06/01/2003 - "These results indicate (i) that the host cell receptor(s) and entry machinery for KSHV are widely distributed on cultured adherent cells, (ii) that latency is the default pathway of infection, and (iii) that blocks to lytic induction are frequent and largely reside at or upstream of the expression of KSHV RTA." 12/20/1998 - "Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein."
2.	Virus Diseases (Viral Diseases) 06/05/2002 - "HIV gene expression activated the KSHV Rta promoter following viral infection or after transfection of proviral DNA. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	DNA (Deoxyribonucleic Acid)