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taxuspine C

taxoid isolated from the Japanese yew Taxus cuspidata; structure in first source; do not confuse with taxuspin C

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Akiyama, S: 1 article (06/2000)
2.	Chen, Z: 1 article (06/2000)
3.	Hosoyama, H: 1 article (06/2000)
4.	Kobayashi, J: 1 article (06/2000)
5.	Naito, M: 1 article (06/2000)
6.	Shigemori, H: 1 article (06/2000)
7.	Tsuruo, T: 1 article (06/2000)

Related Diseases

1.

Neoplasms (Cancer)

06/01/2000 - "Taxuspine C, 2'-desacetoxyaustrospicatine, and 2-desacetoxytaxinine J may be candidate pharmaceuticals for reversing multidrug resistance (MDR) and also may be good modifiers of MDR in cancer chemotherapy."
07/01/1998 - "This indicates that the 5-O-benzoylated taxuspine C derivative may be a promising functional inhibitor of P-glycoprotein, which acts as an ATP-associated efflux pump for cancer chemotherapeutic agents."
06/16/1998 - "Taxuspine C (1), a new taxoid from the Japanese yew Taxus cuspidata, increasing the cellular accumulation of vincristine (VCR) in multidrug-resistant tumor cells as potent as verapamil enhanced the chemotherapeutic effect of VCR in P388/VCR-bearing mice. "

Related Drugs and Biologics

1.	Taxoids (Taxanes)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Vincristine (Oncovin)
4.	Verapamil (Calan)
5.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)