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soyasapogenol A

RN refers to (3beta,4beta,21beta,22beta)-isomer; structure in first source

Also Known As:

olean-12-ene-3,21,22,23-tetrol

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Oleanolic Acid: 547
        soyasapogenol A: 5
      - Sapogenins: 26
        Oleanolic Acid: 547
        soyasapogenol A: 5

Experts

1.	Elwakeel, Ahmed: 1 article (01/2020)
2.	Kalra, Rajkumar Singh: 1 article (01/2020)
3.	Kaul, Sunil C: 1 article (01/2020)
4.	Omar, Amr: 1 article (01/2020)
5.	Putri, Jayarani: 1 article (01/2020)
6.	Wadhwa, Renu: 1 article (01/2020)
7.	Kamo, Shuichi: 1 article (05/2014)
8.	Sato, Toshiro: 1 article (05/2014)
9.	Suzuki, Shunsuke: 1 article (05/2014)
10.	Gurfinkel, D M: 1 article (01/2003)

Related Diseases

1.	Hepatitis 03/10/2000 - "Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model." 03/10/2000 - "The present study was carried out to analyze the effects of soyasapogenol A on the liver injury mediated by the immune response in concanavalin A-induced hepatitis in mice. " 03/10/2000 - "Since the effect of soyasapogenol A on the elevated plasma TNF-alpha level was not appreciable compared to the preventive effect of soyasapogenol A on the elevated plasma alanine aminotransferase level, these results suggest that soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-alpha, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model."
2.	Colonic Neoplasms (Colon Cancer) 01/01/2003 - "In this study, therefore, purified soyasaponins and soyasapogenins were tested for their ability to suppress the growth of HT-29 colon cancer cells, as determined by the WST-1 assay, over a concentration range of 0-50 ppm. Soyasaponin I and III, soyasapogenol B monoglucuronide, soyasapogenol B, soyasaponin A1, soyasaponin A2, and soyasapogenol A were evaluated. " 05/01/2014 - "The apical-to-basolateral absorption of soyasapogenol B in the Caco-2 human colon cancer monolayer cell model (apparent permeability coefficient [Papp], 5.5 × 10(-6) cm/sec) was higher than that of soyasapogenol A (Papp, 1.6 × 10(-6) cm/sec). "
3.	Neoplasms (Cancer) 01/01/2020 - "Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells." 01/01/2020 - "We screened some phytochemicals for cytotoxic activity to human cancer cells and identified Soyasapogenol-A (Snol-A) as a potent candidate anti-cancer compound. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells."
5.	Breast Neoplasms (Breast Cancer) 12/01/2002 - "Two soy sapogenols, soyasapogenol A (SA) and soyasapogenol B (SB) were tested for their estrogenic activities in estrogen responsive MCF-7 or estrogen-insensitive MDA-MB-231 (MDA) human breast cancer cells. "

Related Drugs and Biologics

1.	Concanavalin A
2.	soyasapogenol B
3.	soyasaponin I
4.	Phytochemicals
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Estrogens (Estrogen)
7.	Alanine Transaminase (SGPT)
8.	LY 165163 (PAPP)