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acetyl-leucinal-nor-leucinal

peptide aldehyde

Also Known As:

ALLnL

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Leucine: 6718
      - acetyl-leucinal-nor-leucinal: 3
  - Essential Amino Acids: 1152
    - Leucine: 6718
      - acetyl-leucinal-nor-leucinal: 3

Experts

1.	Li, Q Q: 2 articles (10/2001 - 05/2000)
2.	Reed, E: 2 articles (10/2001 - 05/2000)
3.	Jones, L N: 1 article (10/2001)
4.	Kayastha, G L: 1 article (10/2001)
5.	Mimnaugh, E G: 1 article (10/2001)
6.	Neckers, L: 1 article (10/2001)
7.	Yu, J J: 1 article (10/2001)
8.	Yunmbam, M K: 1 article (10/2001)
9.	Ding, L: 1 article (05/2000)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2001 - "Our results showed that ALLnL, at its respective IC20 concentration, increased cellular sensitivity to cisplatin in an additive manner in human ovarian cancer A2780, A2780/CP70, and OVCAR3 cells. "
2.	Neuroblastoma 12/04/1996 - "Treatment of neuroblastoma cultures with N-methyl-D-aspartate (NMDA) or human immunodeficiency virus type 1 (HIV-1) coat protein, gp120, induces significant cytotoxic effects which are reduced by leupeptin, E-64, N-Ac-Leu-Leu-norleucinal (ALLnL) as well as by N-Ac-Leu-Leu-normethioninal (ALLnM) and this suggests that activation of the Ca(2+)-dependent protease, calpain, is involved. "
3.	Neoplasms (Cancer) 10/01/2001 - "Effect of the proteasome inhibitor ALLnL on cisplatin sensitivity in human ovarian tumor cells."
4.	Carcinoma (Carcinomatosis) 05/01/2000 - "We have recently shown that ALLnL, at concentrations that do not appear harmful, has significantly enhanced DNA platination and decreased DNA repair of cisplatin-DNA adducts in human A2780/CP70 ovarian carcinoma cells. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Proteasome Inhibitors
3.	DNA Adducts
4.	N-Methylaspartate (NMDA)
5.	Proteins (Proteins, Gene)
6.	Peptide Hydrolases (Proteases)
7.	DNA (Deoxyribonucleic Acid)
8.	Calpain
9.	acetyl-leucinal-leucinal-normethional
10.	acetylleucyl-leucyl-norleucinal