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DW 166HC

a holmium-166-chitosan complex

Also Known As:

DW-166HC

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Chitin: 898
      - DW 166HC: 2
Carbohydrates: 22023
- Polysaccharides: 15383
  - Chitin: 898
    - DW 166HC: 2
Organic Chemicals: 133
- Organometallic Compounds: 64
  - DW 166HC: 2

Experts

1.	Hong, Sung Kyu: 1 article (12/2005)
2.	Kwak, Cheol: 1 article (12/2005)
3.	Lee, Sang Eun: 1 article (12/2005)
4.	Park, Moon Soo: 1 article (12/2005)
5.	Ryu, Jei Man: 1 article (12/2005)
6.	Seong, Seung Kyoo: 1 article (12/2005)
7.	Kim, K H: 1 article (04/2001)
8.	Lee, J D: 1 article (04/2001)
9.	Lee, S H: 1 article (04/2001)
10.	Lee, S K: 1 article (04/2001)

Related Diseases

1.	Synovitis 04/01/2001 - "These results suggest that DW-166HC might be a safe agent for radiation synovectomy, particularly for the treatment of knee synovitis of RA, and further trials in a larger patient population are warranted to evaluate the therapeutic efficacy of DW-166HC." 04/01/2001 - "Based on these findings, we conducted a phase I/IIa study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA). " 04/01/2001 - "A total of 16 patients [1 man, 15 women; median age 49 (range 36-65) years] who had RA knee synovitis refractory to disease-modifying anti-rheumatic drug treatments of > 3 months' duration were randomly assigned to three treatment groups with different radiation doses of DW-166HC: 370 MBq (n = 6), 555 MBq (n = 5) and 740 MBq (n = 5). "
2.	Rheumatoid Arthritis 04/01/2001 - "Based on these findings, we conducted a phase I/IIa study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA). "
3.	Neoplasms (Cancer) 12/01/2005 - "Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate. " 12/01/2005 - "First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. "

Related Drugs and Biologics

1.	Chitosan
2.	Antirheumatic Agents (DMARD)
3.	Solutions
4.	Saline Solution

Related Therapies and Procedures

1.	Synovectomy
2.	Injections