Electron Transport Complex I

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.

Also Known As:

NADH-CoQ Reductase; NADH Dehydrogenase (Ubiquinone); NADH-Coenzyme Q Reductase; Complex I Dehydrogenase; NADH DH I; NADH Dehydrogenase Complex 1; NADH Dehydrogenase I; NADH Q1 Oxidoreductase; NADH-Ubiquinone Oxidoreductase; NADH-Ubiquinone Reductase; Respiratory Complex I; Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase; Ubiquinone Reductase; Dehydrogenase, Complex I; NADH CoQ Reductase; NADH Coenzyme Q Reductase; NADH Ubiquinone Oxidoreductase; NADH Ubiquinone Reductase; Oxidoreductase, NADH Q1; Oxidoreductase, NADH-Ubiquinone; Reductase, NADH-Ubiquinone; Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - Electron Transport Complex I: 370
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - NADPH Oxidoreductases NADH
      - Electron Transport Complex I: 370
  - Multienzyme Complexes: 8
    - Electron Transport Chain Complex Proteins
      - Electron-Transferring Flavoproteins: 82
        Electron Transport Complex I: 370
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Proton Pumps: 415
        Electron Transport Complex I: 370
    - Iron-Binding Proteins: 172
      - Nonheme Iron Proteins
        Iron-Sulfur Proteins: 42
        Electron Transport Complex I: 370
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Proton Pumps: 415
        Electron Transport Complex I: 370
    - Electron Transport Chain Complex Proteins
      - Electron-Transferring Flavoproteins: 82
        Electron Transport Complex I: 370
  - Flavoproteins: 234
    - Electron-Transferring Flavoproteins: 82
      - Electron Transport Complex I: 370
  - Metalloproteins: 164
    - Iron-Binding Proteins: 172
      - Nonheme Iron Proteins
        Iron-Sulfur Proteins: 42
        Electron Transport Complex I: 370

human NDUFA8 protein

Bio-Agent Context: Research Results