AWD 131-138

10/01/2014 - "Imepitoin as novel treatment option for canine idiopathic epilepsy: pharmacokinetics, distribution, and metabolism in dogs."
06/12/2017 - "In summary, imepitoin was well tolerated in healthy and epileptic cats and showed in a pilot trial indication for efficacy in treating feline epilepsy."
08/05/2017 - "Long-term efficacy of imepitoin in the treatment of naive dogs affected by idiopathic epilepsy."
08/05/2017 - "The purpose of this study was to evaluate the long-term (12 months) efficacy and tolerability of imepitoin as first-choice treatment in 56 dogs suffering from idiopathic epilepsy and identify possible factors affecting the outcome. "
08/01/2015 - "Study on the effects of imepitoin on the behaviour of dogs with epilepsy."

11/01/2022 - "Imepitoin was frequently selected in the treatment of cluster seizures despite no authorisation for this purpose. "
04/01/2016 - "The dosage of imepitoin was increased from 20 mg/kg twice daily to 30 mg/kg twice daily, 3 days before the onset of skin lesions, due to uncontrolled seizures. "
11/01/2013 - "Effective doses of imepitoin in the PTZ seizure model were in the same range as those suppressing spontaneous recurrent seizures in epileptic dogs. "
07/01/2016 - "Since early 2013, imepitoin has been used in most European countries for the management of recurrent single generalised epileptic seizures in dogs with idiopathic epilepsy. "
10/01/2004 - "In the present study, the new low-affinity partial BZD-receptor agonist ELB 138 [former name AWD 131-138; 1-(4-chlorophenyl)-4-morpholino-imidazolin-2-one] was evaluated in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. "

11/01/2020 - "Imepitoin for treatment of idiopathic head tremor syndrome in dogs: A randomized, blinded, placebo-controlled study."
11/01/2020 - "Prospective, blinded, placebo-controlled clinical trial to compare imepitoin with placebo in dogs with frequent episodes of idiopathic head tremor. "

06/25/2016 - "The aim of this study was to compare ataxia levels in dogs with IE treated chronically with phenobarbitone or imepitoin, the two currently available first-line AED treatments. "
06/25/2016 - "These results indicate that dogs treated with phenobarbitone experience ataxia compared with controls and imepitoin-treated dogs. "

02/01/2020 - "Engel O, Müller HW, Klee R et al. Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs. "
11/01/2019 - "Imepitoin effectively controls fear and anxiety associated with noise phobia in dogs."
11/01/2019 - "To evaluate the efficacy and safety of imepitoin in comparison to placebo for the control of anxiety and fear associated with noise phobia in dogs. "
11/01/2019 - "Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs."