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MJ 451
potassium channel opener; structure in first source
Also Known As:
6-cyano-3,4-dihydro-2,2-dimethyl-2H-3-hydroxy-4-(2-oxo-1-(hydroxymethyl)-1-pyrrolidinyl)-1-benzopyran; MJ 355; MJ-355; MJ-451
Networked:
1
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
MJ 451: 1
Pyrrolidines: 115
Pyrrolidinones: 162
MJ 451: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
MJ 451: 1
Related Diseases
1.
Myocardial Infarction
10/01/1999 - "
It is suggested that MJ-355 should be useful in the treatment of hypertension and/or acute myocardial infarction.
"
2.
Hypertension (High Blood Pressure)
10/01/1999 - "
It is suggested that MJ-355 should be useful in the treatment of hypertension and/or acute myocardial infarction.
"
3.
Myocardial Ischemia (Ischemic Heart Diseases)
10/01/1999 - "
In myocardial ischemia, pretreatment of MJ-355 (0.02 mg/kg) significantly reduced the total number of ventricular premature contractions and ventricular tachycardia, total duration of ventricular fibrillation and the mortality.
"
10/01/1999 - "
The effects of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
"
10/01/1999 - "
This study was designed to evaluate the effect of MJ-355 (6-cyano-3,4-trans-3,4-dihydro-2,2-dimethyl-2H-3-hydroxy-4-[2-oxo-5S-(1- ethoxyethoxymethyl)-1-pyrrolidinyl]-1-benzopyran), a newly synthesized K(ATP) channel opener, on hemodynamics in spontaneously hypertensive rats and on myocardial ischemia-reperfusion injury in a rat model of 45 min left coronary artery occlusion followed by 1-h reperfusion.
"
4.
Reperfusion Injury
10/01/1999 - "
The effects of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
"
10/01/1999 - "
This study was designed to evaluate the effect of MJ-355 (6-cyano-3,4-trans-3,4-dihydro-2,2-dimethyl-2H-3-hydroxy-4-[2-oxo-5S-(1- ethoxyethoxymethyl)-1-pyrrolidinyl]-1-benzopyran), a newly synthesized K(ATP) channel opener, on hemodynamics in spontaneously hypertensive rats and on myocardial ischemia-reperfusion injury in a rat model of 45 min left coronary artery occlusion followed by 1-h reperfusion.
"
5.
Ventricular Tachycardia
10/01/1999 - "
In myocardial ischemia, pretreatment of MJ-355 (0.02 mg/kg) significantly reduced the total number of ventricular premature contractions and ventricular tachycardia, total duration of ventricular fibrillation and the mortality.
"
Related Drugs and Biologics
1.
Benzopyrans
2.
Adenosine Triphosphate (ATP)
3.
KATP Channels