CR 2945

a member of non-peptide CCKB receptor antagonist

Also Known As:

CR-2945; CR2945; beta-(2-((2-(azaspiro(4.5)dec-8-ylcarbonyl)-4,6-dimethylphenyl)amino)-2-oxoethyl)-(R)-1-naphthalenepropanoic acid

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        CR 2945: 5

Experts

1.	Donato, F: 2 articles (01/2002 - 03/2001)
2.	Fontana, M G: 2 articles (01/2002 - 03/2001)
3.	Moneghini, D: 2 articles (01/2002 - 03/2001)
4.	Villanacci, V: 2 articles (01/2002 - 03/2001)
5.	Rindi, G: 1 article (01/2002)
6.	Ghirardi, M: 1 article (03/2001)
7.	La Pinta, M: 1 article (03/2001)
8.	Salerni, B: 1 article (03/2001)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/1999 - "Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1, 2-dimethylhydrazine-induced colorectal cancer in mice." 01/01/1999 - "This study tested the effect of a new gastrin receptor antagonist, CR2945, on colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in mice. " 01/01/2002 - "We aimed to assess whether the CCK-B/gastrin receptor antagonist, CR2945, may prevent the development of ACF and adenocarcinoma in the experimental model of dimethylhydrazine (DMH)-induced colorectal cancer. "
2.	Carcinogenesis 03/01/2001 - "The aim of this study is to test the effect of CR2945 on the appearance and distribution of aberrant crypt foci (ACF), proposed as early "preneoplastic" lesions in colon carcinogenesis, in the murine model. "
3.	Aberrant Crypt Foci 03/01/2001 - "The aim of this study is to test the effect of CR2945 on the appearance and distribution of aberrant crypt foci (ACF), proposed as early "preneoplastic" lesions in colon carcinogenesis, in the murine model. " 03/01/2001 - "Distribution of 1,2 DMH-induced colonic aberrant crypt foci after administration of a gastrin receptor antagonist (CR2945), in the murine model."
4.	Colonic Neoplasms (Colon Cancer) 01/01/1999 - "These data show that CR2945 could prevent chemically induced colon cancer development in mice." 03/01/2001 - "Our previous experimental data demonstrated that a new gastrin receptor antagonist (CR2945) has a chemopreventive effect on dimethylhydrazine-induced colon cancer in mice. "
5.	Stomach Ulcer (Gastric Ulcer) 03/12/1999 - "CR 2945 was about as efficacious as ranitidine against the indomethacin- and ethanol-induced gastric ulcers and the cysteamine-induced duodenal ulcer in rats. "

Related Drugs and Biologics

1.	Cholecystokinin B Receptor
2.	Dimenhydrinate (DMH)
3.	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)
4.	Dimethylhydrazines
5.	Ranitidine (Zantac)
6.	Indomethacin (Indometacin)
7.	Diazepam (Valium)
8.	Cysteamine (Mercaptamine)
9.	Ethanol (Ethyl Alcohol)