mgcRacGAP

specifically activates GTPases of Rac and CDC42 GTP-binding proteins.

Also Known As:

Cyk-4 protein, human; RACGAP1, human; Rac GTPase-activating protein 1, human SY RACGAP1; male germ cell racGAP

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - GTPase-Activating Proteins: 445
        mgcRacGAP: 7
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - GTPase-Activating Proteins: 445
        mgcRacGAP: 7

Experts

1.	Kitamura, Toshio: 2 articles (12/2004 - 02/2004)
2.	Işık Gönül, İpek: 1 article (10/2016)
3.	Seçkin, Selda: 1 article (10/2016)
4.	Uluoğlu, Ömer: 1 article (10/2016)
5.	Çakır, Aslı: 1 article (10/2016)
6.	Şahin, Sevinç: 1 article (10/2016)
7.	Fagerholm, Annika: 1 article (01/2015)
8.	Koskinen, Ari: 1 article (01/2015)
9.	Lehto, Anna: 1 article (01/2015)
10.	Repasky, Gretchen A: 1 article (01/2015)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/01/2016 - "Objectives The aims of this study are to evaluate expressions of Ki67, RacGAP1 (MgcRacGAP) and topoisomerase 2 alpha (TOP2a), the markers related with cell proliferation that have been proposed to affect the prognosis in the literature and correlate the results with clinicopathological parameters of breast cancer patients. "
2.	Neoplasms (Cancer) 06/01/2013 - "We additionally present results indicating that MgcRacGAP binding to HIF-1α is specific, since it does not affect the transcriptional activity of HIF-2, a close evolutionary relative of HIF-1 also involved in hypoxia regulation and cancer. " 01/01/2015 - "To this end, we designed a biochemical, high throughput screening assay with complementary follow-up assays to identify small molecule compounds inhibiting MgcRacGAP, a Rho family GTPase activating protein involved in cytokinesis and transcriptionally upregulated in many cancers. "
3.	Male Infertility (Male Sterility) 02/15/2014 - "We found that the absence of MgcRacGAP induced a germline depletion and male sterility. " 02/15/2014 - "Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse." 03/13/1998 - "Since rotundRacGAP deletion leads to male sterility in the fruit fly, the mgcRacGAP gene may prove likewise to play a key role in mammalian male fertility."
4.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 03/13/1998 - "A protein of the predicted size 58 kDa, which we call MgcRacGAP, was detected in human testis as well as in germ cell tumor extracts by immunoblotting with antibodies specific to recombinant protein. "
5.	Leukemia 12/01/2004 - "We previously identified a guanosine triphosphatase (GTPase)-activating protein (GAP) male germ cell Rac GAP (MgcRacGAP) that enhanced interleukin-6 (IL-6)-induced macrophage differentiation of murine M1 leukemia cells. "

Related Drugs and Biologics

1.	GTPase-Activating Proteins (GTPase-Activating Protein)
2.	Interleukin-6 (Interleukin 6)
3.	Recombinant Proteins
4.	Proteins (Proteins, Gene)
5.	Guanosine
6.	Antibodies