berberrubine

RN refers to chloride salt; a protoberberine alkaloid antitumor agent which exhibits topoisomerase II poison activity as well as catalytic inhibition activity; structure in first source

Also Known As:

Networked: 17 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wu, Jin-Yi: 2 articles (07/2022 - 09/2021)
2.	Cao, Shijie: 2 articles (10/2018 - 01/2018)
3.	Qiu, Feng: 2 articles (10/2018 - 01/2018)
4.	Dian, Lulu: 1 article (08/2022)
5.	Drobot, Liudmyla: 1 article (08/2022)
6.	Horak, Iryna: 1 article (08/2022)
7.	Li, Jinhua: 1 article (08/2022)
8.	Lu, Hongfei: 1 article (08/2022)
9.	Sun, Yanfang: 1 article (08/2022)
10.	Wang, Juan: 1 article (08/2022)

Related Diseases

1.	Thrombosis (Thrombus) 01/05/2023 - "This study aims to investigate the effects and mechanisms of berberrubine, a main metabolite of berberine, to inhibit thrombus formation. " 01/05/2023 - "Carrageenan-induced mouse tail thrombosis model was used to evaluate the effects of berberrubine hydrochloride (BBB) on thrombus formation in vivo. " 01/05/2023 - "Integrated metabolomics and molecular docking reveal berberrubine inhibits thrombosis by regulating the vitamin K catalytic cycle in mice."
2.	Hepatocellular Carcinoma (Hepatoma) 02/01/2019 - "In a previous study, we have indicated that berberrubine (M3), a major metabolite of BBR in vivo, displays the most potential hypolipidemic effects via upregulating LDLR expression in human hepatoma (HepG2) cells compared with BBR and 3 other metabolites. " 02/01/2019 - "Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells."
3.	Ulcerative Colitis 02/01/2022 - "The results of comparative analysis of differences indicated that puerarin, baicalin, wogonoside, wogonin, chrysin, oroxylin A, berberine, berberrubine, and palmatine were the characteristic components in model state, which at the same time, were confirmed by pharmacological studies to be the serum pharmacodynamic material basis of Gegen Qinlian Decoction in the treatment of ulcerative colitis. "
4.	Neoplasms (Cancer) 12/01/2023 - "Furthermore, oral administration of berberrubine remarkably reduced tumor volume and weight in a human cell line-derived xenograft model. " 09/13/2021 - "9-O-Terpenyl-Substituted Berberrubine Derivatives Suppress Tumor Migration and Increase Anti-Human Non-Small-Cell Lung Cancer Activity." 12/01/2023 - "Importantly, the anti-cancer activity of berberrubine was also confirmed by using the azoxymethane (AOM) / dextran sulfate sodium (DSS)-induced spontaneous CRC mouse model. " 11/17/1998 - "Taken together, these results indicate that berberrubine represents a new class of antitumor agent which exhibits the topoisomerase II poison activity as well as catalytic inhibition activity and may have a potential clinical value in cancer treatment." 01/01/2018 - "Berberrubine, an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects. "
5.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2023 - "Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer." 04/01/2002 - "To better understand the mechanisms of cellular response to berberrubine, human colorectal carcinoma cells (AMC5) were selected for resistance to berberrubine. " 04/01/2002 - "Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine."

Related Drugs and Biologics

1.	Berberine
2.	gegenqinlian
3.	wogonoside
4.	wogonin
5.	5,7- dihydroxy- 6- methoxy- 2- phenylchromen- 4- one
6.	chrysin
7.	baicalin
8.	puerarin
9.	palmatine
10.	Alkaloids

Related Therapies and Procedures

1.	Oral Administration