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glutamate receptor type B

AMPA receptor subunit; amino acid sequence in first source

Also Known As:

GluR-B

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seeburg, Peter H: 2 articles (11/2004 - 11/2004)
2.	Sprengel, Rolf: 2 articles (11/2004 - 11/2004)
3.	Du, Chao: 1 article (06/2015)
4.	Han, Liang: 1 article (06/2015)
5.	Li, Zhaohui: 1 article (06/2015)
6.	Tian, Nan: 1 article (06/2015)
7.	Tian, Yu: 1 article (06/2015)
8.	Zhang, Haishan: 1 article (06/2015)
9.	Zhao, Xingli: 1 article (06/2015)
10.	Ahmadi, Seifollah: 1 article (11/2004)

Related Diseases

1.	Ischemia 12/01/1993 - "Following global ischemia, the levels of GluR-B flip and flop variants are dramatically reduced (90-100%), well before any morphological signs of cell death, in the subiculum and CA1, two areas known to be particularly sensitive to ischemic insult. " 12/01/1993 - "Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia." 04/01/2002 - "Ischemia and ischemic tolerance induction differentially regulate protein expression of GluR1, GluR2, and AMPA receptor binding protein in the gerbil hippocampus: GluR2 (GluR-B) reduction does not predict neuronal death."
2.	Seizures (Absence Seizure) 04/30/1999 - "This AMPA receptor-mediated LTP at CA3/CA1 synapses was also observed in mice that carry an editing-deficient GluR-B allele even though these mice die prematurely after heavy epileptic seizures. " 12/08/1995 - "These mice developed seizures and died by 3 weeks of age, showing that GluR-B pre-mRNA editing is essential for brain function." 12/14/1992 - "In comparison to control animals, the expression level of the Flip variant of both GluR-A and GluR-B mRNAs was bilaterally enhanced in the dentate granule neurons of kindled animals 24 h after last-generalized seizure, whereas no obvious alterations were observed in the GluR-A Flop and GluR-B Flop mRNA variants. " 11/17/2004 - "Premature death from seizures afflicts gene-targeted mice expressing the Q/R site-unedited glutamate receptor subunit GluR-B(Q) of AMPA receptors in central neurons. "
3.	Glioma (Gliomas) 06/01/2015 - "We confirmed the underediting at the Q/R site of GluR-B mRNA in the glioma cell lines U87, U251 and A172 compared with that in normal human astrocytes (NHAs) HA1800. " 12/04/2001 - "Underediting of glutamate receptor GluR-B mRNA in malignant gliomas." 06/01/2015 - "ADAR2 is the main enzyme responsible for A-to-I editing in humans, and A-to-I underediting at the glutamine (Q)/arginine (R) site of the glutamate receptor subunit B (GluR-B) is associated with the pathogenesis and invasiveness of glioma. "
4.	Epilepsy (Aura) 12/08/1995 - "Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice." 12/01/1993 - "Using in situ hybridization techniques, we show that kainate-induced epilepsy provokes a rapid but transient increase (50%) of GluR-B flip mRNA levels in all subregions of the hippocampus (CA1, CA3, dentate gyrus). " 12/01/1993 - "Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia."
5.	Pain (Aches) 11/18/2004 - "The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain."

Related Drugs and Biologics

1.	AMPA Receptors (AMPA Receptor)
2.	Messenger RNA (mRNA)
3.	Glutamate Receptors (Glutamate Receptor)
4.	RNA Precursors (Precursor, mRNA)
5.	Proteins (Proteins, Gene)
6.	Kainic Acid (Kainate)
7.	Glutamine (L-Glutamine)
8.	Enzymes
9.	Carrier Proteins (Binding Protein)
10.	Arginine (L-Arginine)