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N- (2- chloroethyl)- N- nitrosoureidodaunorubicin

structure in first source

Also Known As:

AD-312

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - N-(2-chloroethyl)-N-nitrosoureidodaunorubicin: 1
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - N-(2-chloroethyl)-N-nitrosoureidodaunorubicin: 1

Related Diseases

1.	Cardiotoxicity 01/01/1998 - "N-(2-Chloroethyl)-N-nitrosoureidodaunorubicin (AD 312), a novel semisynthetic compound with combined anthracycline and nitrosourea alkylating functionalities, circumvents resistance conferred by either reduced DNA topoisomerase II (topo II) or increased P-glycoprotein expression with less myelosuppression and cardiotoxicity than adriamycin (doxorubicin; ADR). "

Related Drugs and Biologics

1.	Member 1 Subfamily B ATP Binding Cassette Transporter
2.	Anthracyclines
3.	Doxorubicin (Adriamycin)
4.	Type II DNA Topoisomerases (Topoisomerase II)
5.	trioctyl phosphine oxide (TOPO)