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tPA stop

a tissue plasminogen activator inhibitor; no further information available 11/98

Also Known As:

2,7-bis-(4-amidino-benzylidene)-cycloheptan-1-one dihydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cycloheptanes
        tPA stop: 2

Experts

1.	Dai, Yi: 1 article (04/2007)
2.	Kobayashi, Kimiko: 1 article (04/2007)
3.	Kozai, Toyoko: 1 article (04/2007)
4.	Mashimo, Takashi: 1 article (04/2007)
5.	Noguchi, Koichi: 1 article (04/2007)
6.	Obata, Koichi: 1 article (04/2007)
7.	Yamanaka, Hiroki: 1 article (04/2007)
8.	Ali, Carine: 1 article (10/2004)
9.	Benchenane, Karim: 1 article (10/2004)
10.	Buisson, Alain: 1 article (10/2004)

Related Diseases

1.	Pain (Aches) 04/15/2007 - "In contrast, the delayed administration of tPA-STOP during the chronic stage of injury (10 days) did not affect pain behavior. "
2.	Necrosis 10/01/2004 - "In mouse cortical cell cultures, we observed that although tPA stop reduced N-methyl-D-aspartic acid (NMDA)-mediated excitotoxic neuronal death, it failed to modulate alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazole propanoic acid or kainate-mediated necrosis. "
3.	Hyperalgesia 04/15/2007 - "Intrathecal and continuous administration of tPA inhibitor, tPA-STOP, suppressed root ligation-induced mechanical allodynia in a dose-dependent manner during an early stage of injury (0-4 days). "

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Propionates
3.	Kainic Acid (Kainate)

Related Therapies and Procedures

1.	Ligation