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2-deoxy-glucose tetraacetate

inhibitor of D-glucose metabolism in differnt cell types

Also Known As:

2-DOG TA; 2-deoxy-D-glucose tetraacetate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Sugars: 11126
  - Monosaccharides: 889
    - Hexoses: 549
      - Glucose: 147007
        2-deoxy-glucose tetraacetate: 3

Experts

1.	Kadiata, M M: 1 article (09/2000)
2.	Malaisse, W J: 1 article (09/2000)
3.	Nadi, A B: 1 article (09/2000)
4.	Olivares, E: 1 article (09/2000)
5.	Reinhold, U: 1 article (09/2000)
6.	Tilgen, W: 1 article (09/2000)
7.	Ugurel, S: 1 article (09/2000)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 09/01/2000 - "Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells." 02/01/1998 - "Likewise, 2-deoxy-D-glucose tetraacetate exerted a time-related (4-72 h) and concentration-related (0.1-1.0 mM) cytotoxic action upon human melanoma cells of the Colo 38 line. " 02/01/1998 - "Cytotoxic action of 2-deoxy-D-glucose tetraacetate upon human lymphocytes, fibroblasts and melanoma cells."
2.	Body Weight (Weight, Body) 11/01/1999 - "The gain in body weight and survival time were measured in untreated animals and mice injected intraperitoneally 1, 5 and 9 days after the administration of the tumoral cells with 5-fluorouracil (20-200 microg/g body wt.) and/or 2-deoxy-D-glucose tetraacetate (75 or 1,350 microg/g body wt.). " 11/01/1999 - "Although 2-deoxy-D-glucose tetraacetate, when tested in the low dose of 75 microg/g body weight opposed the effect of 5-fluorouracil on survival time, a higher dose of the ester (1,350 microg/g body weight) potentiated the effect of 5-fluorouracil to both decrease body weight gain and increase survival time. "
3.	Ascites 11/01/1999 - "Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells."

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Esters