calcium-independent protein kinase C

induces apoptosis in thymocytes; nPKC-delta & -epsilon are isoforms; see also nPKCtheta protein

Also Known As:

Ca(2+)-independent PKC; nPKC-delta; nPKC-epsilon

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Protein Kinase C: 5856
        calcium-independent protein kinase C: 15
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Protein Kinase C: 5856
        calcium-independent protein kinase C: 15

Experts

1.	Jin, Zhu: 1 article (10/2015)
2.	Liu, Fang: 1 article (10/2015)
3.	Wang, Xiaofang: 1 article (10/2015)
4.	Zhang, Wenhui: 1 article (10/2015)
5.	Zheng, Yanqian: 1 article (10/2015)
6.	Zhi, Jianming: 1 article (10/2015)
7.	Kazdová, L: 1 article (01/2010)
8.	Marková, I: 1 article (01/2010)
9.	Mlejnek, P: 1 article (01/2010)
10.	Musilová, A: 1 article (01/2010)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1993 - "Detailed analysis of seven individual nPKC epsilon overproducing clones indicated that those clones that expressed very high activity displayed a number of disorders in growth control, including: formation of dense foci in monolayer culture, decreased doubling time, increased saturation density, decreased serum requirement, growth in soft agar, and tumor formation in nude mice. " 09/01/2009 - "Indeed, since coleon U has no effect on cPKCs and aPKC, recognised as anti-apoptotic proteins, and selectively induces an apoptotic pathway dependent on nPKC-delta and -epsilon activation, it represents a promising compound for evaluation as an anti-cancer drug."
2.	Glioma (Gliomas) 02/01/1995 - "Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells. " 01/11/1999 - "Myristoylated alanine-rich C-kinase substrate is phosphorylated and translocated by a phorbol ester-insensitive and calcium-independent protein kinase C isoform in C6 glioma cell membranes."
3.	Carcinogenesis 08/01/1994 - "No evidence for a role of Ca(2+)-independent nPKC delta and aPKC zeta isoenzymes in the early stages of DENA-induced liver carcinogenesis could be demonstrated."
4.	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/01/2010 - "To test this hypothesis, we analyzed long-term metabolic effects of pioglitazone and the activation of nPKC-epsilon and -theta isoforms in an animal model of the metabolic syndrome, the spontaneously hypertensive rat (a congenic SHR strain with wild type Cd36 gene) fed a diet with 60 % sucrose from the age of 4 to 8 months. "
5.	Pre-Eclampsia (Preeclampsia) 10/01/2015 - "εV1-2, but not U-73122, could completely inhibit the amplification response of AT1-AA to Ang II. These results suggest that AT1-AA is able to cause amplification response to Ang II probably via the calcium-independent protein kinase C pathway, which may provide a new therapy strategy for preeclampsia."

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Isoenzymes
3.	Cysteine Proteases (Cysteine Protease)
4.	Protein Kinase C-epsilon
5.	Protein Kinase C-alpha
6.	Apoptosis Regulatory Proteins
7.	Protein Tyrosine Phosphatases
8.	Cytokines
9.	Turpentine
10.	Sucrose (Saccharose)

Related Therapies and Procedures

1.	Therapeutics