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FP-TZTP

a subtype selective muscarinic cholinergic ligand

Also Known As:

3-(3-(3-fluoropropyl)thio)-1,2,5-thiadiazol-4-yl-1,2,5,6-tetrahydro-1-methylpyridine

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - FP-TZTP: 4
  - Pyridines: 88
    - FP-TZTP: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - FP-TZTP: 4

Experts

1.	Eckelman, William C: 2 articles (07/2006 - 11/2003)
2.	Kiesewetter, Dale O: 2 articles (07/2006 - 11/2003)
3.	Cannon, Dara M: 1 article (07/2006)
4.	Carson, Richard E: 1 article (07/2006)
5.	Drevets, Michele: 1 article (07/2006)
6.	Drevets, Wayne C: 1 article (07/2006)
7.	Gandhi, Shilpa: 1 article (07/2006)
8.	Nugent, Allison C: 1 article (07/2006)
9.	Rollis, Denise: 1 article (07/2006)
10.	Solorio, Gerardo: 1 article (07/2006)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 03/01/2006 - "Preferential binding of FP-TZTP at the M(2) receptor in vivo led to investigation of [(18)F]FP-TZTP as a potential PET tracer for Alzheimer's disease, in which a substantial reduction of M(2) receptors has been observed in autopsy studies. " 11/01/2003 - "[(18)F][3-(3-(3-Fluoropropyl)thio)-1,2,5-thiadiazol-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine ([(18)F]FP-TZTP) is an M2 selective muscarinic agonist that may allow noninvasive studies of Alzheimer's disease with PET. " 10/01/1998 - "[18F]Fluoropropyl-TZTP (FP-TZTP) is a subtype-selective muscarinic cholinergic ligand with potential suitability for studying Alzheimer's disease. "
2.	Major Depressive Disorder (Major Depressive Disorders) 07/01/2006 - "The M2 receptor binding was compared between unmedicated subjects with major depressive disorder or bipolar disorder during depression vs healthy controls, using positron emission tomography and [18F]FP-TZTP (fluorodopa F 18 [3-(3-[3-fluoroproply]thio)-1,2,5-thiadiazol-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine), a selective M2 receptor radioligand. "
3.	Bipolar Disorder (Manic Depressive Psychosis) 07/01/2006 - "The M2 receptor binding was compared between unmedicated subjects with major depressive disorder or bipolar disorder during depression vs healthy controls, using positron emission tomography and [18F]FP-TZTP (fluorodopa F 18 [3-(3-[3-fluoroproply]thio)-1,2,5-thiadiazol-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine), a selective M2 receptor radioligand. "

Related Drugs and Biologics

1.	Muscarinic Agonists
2.	Cholinergic Agents (Cholinergics)
3.	Ligands
4.	fluorodopa F 18