|1.||Baek, Seung Joon: 6 articles (09/2013 - 05/2006)|
|2.||Cekanova, Maria: 3 articles (07/2010 - 04/2008)|
|3.||Min, Kyung-Won: 2 articles (09/2013 - 09/2012)|
|4.||Imchen, Temjenmongla: 2 articles (09/2013 - 09/2012)|
|5.||McEntee, Michael F: 2 articles (07/2010 - 09/2008)|
|6.||Lee, Seong-Ho: 2 articles (07/2010 - 05/2006)|
|7.||Yamaguchi, Kiyoshi: 2 articles (09/2008 - 05/2006)|
|8.||Manasse, Jorden: 1 article (09/2013)|
|9.||Zhang, Xiaobo: 1 article (09/2012)|
|10.||Wu, Yutian: 1 article (04/2009)|
12/01/1998 - "MCC-555 may prove a useful compound for alleviating the metabolic disturbances and IGT associated with insulin resistance in man."
11/01/1998 - "It is suggested that MCC-555 may provide a causal therapy of insulin resistance by targeted action on the defective site in the insulin signaling cascade."
11/01/1998 - "MCC-555 ameliorates this insulin resistance, producing a 2-fold stimulation of glucose transport, with maximum insulin action being 1.6-fold higher than that in control cells. "
09/01/2008 - "In agreement with in vitro studies, enhanced Muc2 expression was observed in the small intestinal tumors of Min mice treated with MCC-555, suggesting that MUC2 expression may be associated at least in part with the antitumorigenic action of MCC-555. "
02/15/2004 - "Small, well-defined clinical studies using RWJ-241947 are in order for these cancers."
09/01/2013 - "Furthermore, expression of tumor suppressor protein MUC2 was increased in MCC-555 treated mice. "
09/01/2012 - "MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. "
09/01/2008 - "Overall, these results indicate that MCC-555 has a potent tumor suppressor activity in intestinal tumorigenesis, likely involving MUC2 up-regulation by ERK and PPARgamma pathways."
|3.||Colorectal Neoplasms (Colorectal Cancer)
05/01/2006 - "These findings may provide a novel explanation for the antitumorigenic and/or proapoptotic action of MCC-555 in human colorectal cancer and the ability of pharmacologic approaches to be used against diseases caused by alterations of RNA stability."
07/10/2010 - "To elucidate the molecular mechanism(s), by which MCC-555 exerts its effects on the human colorectal cancer cells, we have analyzed the expression of two pro-apoptotic proteins, Krüppel-like factor 4 (KLF4) and nonsteroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1). "
05/01/2006 - "A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells."
04/01/2008 - "In the present study, we examined the alteration of gene expression in HCT-116 human colorectal cancer cells by PPARgamma agonists: MCC-555 (5 microM), rosiglitazone (5 microM), and 15-deoxy-Delta12,14-prostaglandin J2 (1 microM). "
05/01/2006 - "The thiazolidinedione derivative MCC-555 has an apoptotic activity in human colorectal cancer cells, accompanied by up-regulation of a proapoptotic nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in a PPARgamma-independent manner. "
|4.||Aberrant Crypt Foci
|5.||Prostatic Neoplasms (Prostate Cancer)
02/15/2004 - "In vitro studies using various solid and hematological tumor cell lines showed that RWJ-241947 had antiproliferative activity against prostate cancer cells, with the strongest effect against the androgen-independent PC-3 prostate cancer cells. "
02/15/2004 - "RWJ-241947 has surprisingly potent antiproliferative effects against prostate cancer cells in vivo, and it enhances the antitumor activity of As2O3 against myeloma cells. "
02/15/2004 - "Remarkably, in vivo treatment of male beige/nude/X-linked immunodeficient (BNX) mice with RWJ-241947 profoundly suppressed growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue. "
02/15/2004 - "RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide."
|7.||Apoptosis Regulatory Proteins
|10.||Messenger RNA (mRNA)
|1.||Heterologous Transplantation (Xenotransplantation)