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4-(4-methyl-3-pyrrolidinyl)-1H-imidazole dihydrochloride

structure in first source

Also Known As:

Sch 50971; Sch-50971

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 4-(4-methyl-3-pyrrolidinyl)-1H-imidazole dihydrochloride: 3
  - Pyrrolidines: 115
    - 4-(4-methyl-3-pyrrolidinyl)-1H-imidazole dihydrochloride: 3

Experts

1.	Kamei, Chiaki: 1 article (08/2008)
2.	Kuyama, Shoji: 1 article (08/2008)
3.	Ogawa, Masami: 1 article (08/2008)
4.	Yokota, Emiko: 1 article (08/2008)

Related Diseases

1.	Allergic Rhinitis 08/01/2008 - "The aim of this study was to clarify the mechanisms of the inhibitory effect of a histamine H3 receptor agonist, Sch 50971, on nasal signs in an allergic rhinitis model in mice. "
2.	Sneezing 08/01/2008 - "Sch 50971 and cetirizine inhibited antigen-induced sneezing and nasal rubbing in sensitized mice. " 08/01/2008 - "The topical application of a histamine H3 receptor antagonist, clobenpropit, into the nasal cavities resulted in a dose-dependent increase in sneezing and nasal rubbing, and both Sch 50971 and a tachykinin NK1 receptor antagonist, L-733,060, inhibited these reactions in non-sensitized mice. "
3.	Migraine Disorders (Migraine) 10/01/1998 - "In conclusion, Sch 50971 is an orally active, potent and selective agonist of histamine H3 receptors that may act to ameliorate the sequelae of migraine headaches, where activation of histamine H3 receptors may be beneficial. " 10/01/1998 - "We studied the actions of Sch 50971, a novel histamine H3 receptor agonist, in an experimental neurogenic model of migraine and characterized its sedative and respiratory actions. "
4.	Inflammation (Inflammations) 10/01/1998 - "Sch 50971, an orally active histamine H3 receptor agonist, inhibits central neurogenic vascular inflammation and produces sedation in the guinea pig."
5.	Hypertension (High Blood Pressure) 09/01/1998 - "Sch 50971 inhibits sympathetic hypertension evoked by stimulation of the medulla oblongata in anesthetized guinea pigs (ED30 = 0.3 mg/kg i.v., ED30 = 1.0 mg/kg i.d.). "

Related Drugs and Biologics

1.	Histamine H3 Receptors (Histamine H3 Receptor)
2.	Cetirizine (Zyrtec)
3.	Tachykinins
4.	Hypnotics and Sedatives (Sedatives)
5.	Antigens
6.	3- ((3,5- bis(trifluoromethyl)phenyl)methyloxy)- 2- phenylpiperidine
7.	clobenpropit