PKC-3 protein

01/01/2022 - "Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression."

01/01/2022 - "Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression."

06/01/2009 - "Previous studies have indicated that abnormal expression of atypical protein kinase C (aPKC-iota) plays a critical role in occurrence and progression of malignant tumor. "
12/01/2021 - "Atypical protein kinase C (aPKC) are involved in progression of many human cancers. "
01/01/2019 - "Atypical protein kinase C-ι (aPKC-ι) is an oncogenic factor, and required for the epithelial-mesenchymal transition (EMT) of different types of cancer. "
12/18/2018 - "We show that the expression of atypical protein kinase C ζ (PKCζ) and PKCλ/ι was reduced in human serrated tumors. "
11/29/2017 - "We find that the tumor suppressor Discs large (Dlg) links the Par complex component atypical Protein Kinase C (aPKC) to the essential spindle orientation factor GukHolder (GukH). "

09/15/2013 - "During neuroblast asymmetric division, atypical Protein Kinase C (aPKC) activity is tightly regulated; aberrant levels of activity could result in tumorigenesis in third instar larval brain. "
01/01/2019 - "Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. "
11/01/2016 - "Atypical protein kinase C (aPKC) isozymes function in cell polarity, proliferation, and survival, and have also been implicated in carcinogenesis. "
02/05/2016 - "The atypical protein kinase C isoform PRKC iota (PRKCI) plays a key role in cell proliferation, differentiation, and carcinogenesis, and it has been shown to be a human oncogene. "
01/01/2009 - "The atypical protein kinase C (PKC) isoform, PKCzeta, has been shown to interact with the signaling adapter p62, which is important for Ras-induced lung carcinogenesis. "

02/01/2019 - "Previous research has demonstrated that the atypical protein kinase C-ζ (PKC-ζ) is a component of numerous dysregulated pathways in breast cancer, including cellular proliferation, survival, and cell cycle upregulation. "
06/01/2009 - "Our previous study reported that atypical protein kinase C zeta (PKCzeta) regulates epidermal growth factor-induced chemotaxis of human breast cancer cells. "
11/26/2019 - "Here, we found that the overexpression of the protein kinase atypical protein kinase C ι (aPKCi), an oncogene, triggers basally oriented epithelial cell extrusion in vivo as a potential mechanism for early breast tumor cell invasion. "
09/01/2014 - "Here, we report that expression of atypical protein kinase C isoform, PKCλ/ι, significantly increased and activated in all invasive breast cancer (invasive ductal carcinoma or IDC) subtypes including the TNBC subtype. "
12/01/2000 - "Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells."