wolframin protein

encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy; amino acid sequence in first source

Also Known As:

DFNA14 protein, human; DFNA38 protein, human; DFNA6 protein, human; DIDMOAD protein, human; WFS1 protein, human; Wfs1 protein, mouse; Wolfram syndrome 1 (wolframin) protein, human; Wolfram syndrome 1 homolog (human) protein, mouse; wolframin protein, mouse

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - wolframin protein: 4

Experts

1.	Cagalinec, Michal: 1 article (09/2020)
2.	Kureková, Simona: 1 article (09/2020)
3.	Plaas, Mario: 1 article (09/2020)
4.	Aravind, L: 1 article (01/2020)
5.	Burroughs, A Maxwell: 1 article (01/2020)
6.	Iyer, Lakshminarayan M: 1 article (01/2020)
7.	Schäffer, Daniel E: 1 article (01/2020)
8.	Fujioka, Masato: 1 article (01/2016)
9.	Hosoya, Makoto: 1 article (01/2016)
10.	Ogawa, Kaoru: 1 article (01/2016)

Related Diseases

1.	Wolfram Syndrome (Syndrome, Wolfram) 01/01/2020 - "The burst of innovation of new genes in animals included the wolframin protein associated with Wolfram syndrome in humans. " 09/01/2020 - "In previously introduced rat model of Wolfram syndrome, we have shown that in cardiac myocytes lacking functional wolframin protein the calcium transients and contractile response are significantly changed. " 01/01/2016 - "Elucidating the function of wolframin protein in the basal cells of primates would be essential for understanding the pathogenesis of hearing loss in patients with Wolfram syndrome, which may lead to the discovery of new therapeutics."
2.	Hearing Loss (Hearing Impairment) 01/01/2016 - "Elucidating the function of wolframin protein in the basal cells of primates would be essential for understanding the pathogenesis of hearing loss in patients with Wolfram syndrome, which may lead to the discovery of new therapeutics."
3.	Optic Atrophy 11/01/2011 - "The etiology involves a single gene mutation of the wolframin protein inducing endoplasmic reticulum stress and apoptosis in selected cell types with resultant diabetes insipidus, diabetes mellitus, optic atrophy, and sensory-neural deafness. "
4.	Diabetes Mellitus 11/01/2011 - "The etiology involves a single gene mutation of the wolframin protein inducing endoplasmic reticulum stress and apoptosis in selected cell types with resultant diabetes insipidus, diabetes mellitus, optic atrophy, and sensory-neural deafness. "
5.	Diabetes Insipidus 11/01/2011 - "The etiology involves a single gene mutation of the wolframin protein inducing endoplasmic reticulum stress and apoptosis in selected cell types with resultant diabetes insipidus, diabetes mellitus, optic atrophy, and sensory-neural deafness. "

Related Drugs and Biologics

1.	Calcium

Related Therapies and Procedures

1.	Therapeutics