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naamidine A

isolated from the sponge Leucetta; structure in first source

Also Known As:

4-((5-(4-Hydroxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)amino)-1-methyl-1H-imidazole-2,5-dione

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - naamidine A: 4

Experts

1.	Arunachalam, Sasi: 1 article (01/2019)
2.	Gibbons, Joseph B: 1 article (01/2019)
3.	Guillen, Katrin P: 1 article (01/2019)
4.	Looper, Ryan E: 1 article (01/2019)
5.	Pathi, Satya S: 1 article (01/2019)
6.	Salvant, Justin M: 1 article (01/2019)
7.	Santiago, Celine B: 1 article (01/2019)
8.	Sigman, Matthew S: 1 article (01/2019)
9.	Vaden, Rachel M: 1 article (01/2019)
10.	Welm, Bryan E: 1 article (01/2019)

Related Diseases

1.

Neoplasms (Cancer)

07/01/2009 - "Our studies support the continued study of naamidine A and its target(s) for the potential development of better clinical treatments for cancer."
07/01/2009 - "We also find that under conditions where naamidine A inhibits tumor xenograft growth, it induces activation of caspase 3, suggesting that apoptosis is part of its antitumorigenic activity in vivo. "
07/01/2009 - "The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells."
07/01/2007 - "Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A."
01/01/2019 - "A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A."

Related Drugs and Biologics

1.	Alkaloids
2.	Epidermal Growth Factor (EGF)
3.	CSK Tyrosine-Protein Kinase
4.	Caspase 3 (Caspase-3)
5.	Zinc
6.	Ionophores
7.	Antineoplastic Agents (Antineoplastics)