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delta-aminolevulinic acid methyl ester

Also Known As:

5-aminolevulinic acid methyl ester; ALA-ME; aminolevulinic acid methyl ester

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Keto Acids: 203
    - Levulinic Acids
      - Aminolevulinic Acid: 819
        delta-aminolevulinic acid methyl ester: 15
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminolevulinic Acid: 819
    - delta-aminolevulinic acid methyl ester: 15

Experts

1.	Prous, J R: 3 articles (06/2006 - 06/2005)
2.	Rabasseda, X: 3 articles (06/2006 - 06/2005)
3.	Futagami, Masayuki: 2 articles (06/2017 - 01/2016)
4.	Kobayashi, Asami: 2 articles (06/2017 - 01/2016)
5.	Miura, Rie: 2 articles (06/2017 - 01/2016)
6.	Mizunuma, Hideki: 2 articles (06/2017 - 01/2016)
7.	Mizunuma, Makito: 2 articles (06/2017 - 01/2016)
8.	Shigeto, Tatsuhiko: 2 articles (06/2017 - 01/2016)
9.	Yamauchi, Aisa: 2 articles (06/2017 - 01/2016)
10.	Yokoyama, Yoshihito: 2 articles (06/2017 - 01/2016)

Related Diseases

1.	Pain (Aches) 09/01/2003 - "ALA-PDT generated significantly more pain than ALA-ME-PDT during and after illumination (P =.001 and P =.05, respectively). " 09/01/2003 - "The theory that ALA and not ALA-ME is transported by gamma-aminobutyric acid receptors into the peripheral nerve endings may explain the higher pain scores in ALA-PDT-treated areas." 09/01/2003 - "To compare the pain experienced in normal skin treated with 5-aminolevulinic acid (ALA) PDT and 5-aminolevulinic methylester (ALA-ME) PDT. " 10/01/2010 - "Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema."
2.	Neoplasms (Cancer) 06/01/2017 - "Once tumors had developed, 5-aminolevulinic acid methyl ester hydrochloride (methyl-ALA) was administered intraperitoneally and the tumor was irradiated twice/week. " 09/27/2002 - "Topical application of ALA-Me followed by exposure with laser light (633nm) delayed the growth of the tumors slightly. " 09/27/2002 - "However, chemical extraction of tissues excised from mice after intratumoral administration of ALA-Me or its parent compound ALA revealed that this tumor had the capability to produce PpIX. "
3.	Melanoma (Melanoma, Malignant) 09/27/2002 - "No fluorescence of protoporphyrin IX (PpIX) was measured using a fiber optic probe in pigmented B16F10 melanoma in mice after topical application of 5-aminolevulinic acid methylester (ALA-Me). " 01/01/2006 - "This issue focuses on the following selection of drugs: ABT-510, adalimumab, alefacept, ambrisentan, aminolevulinic acid methyl ester, armodafinil, aselizumab, asenapine maleate, azelnidipine; Bevacizumab, bexarotene, bimosiamose, biphasic insulin aspart, bortezomib, bosentan, BQ-123; C340, cannabidiol, caspofungin acetate, CC-4047, certolizumab pegol, cetuximab, ciclesonide, cilansetron, Cypher; Dabigatran etexilate, darbepoetin alfa, darifenacin hydrobromide, desloratadine, dexosome vaccine (melanoma), dimethyl fumarate, dronabinol/cannabidiol, drospirenone, drospirenone/estradiol, drotrecogin alfa (activated), duloxetine hydrochloride, dutasteride; Efalizumab, eglumetad hydrate, emoxipin hydrochloride, eplerenone, erlotinib hydrochloride, escitalopram oxalate, etonogestrel/ethinylestradiol; Garenoxacin mesilate, gamma-hydroxybutyrate sodium, gefitinib; H5N1 pandemic influenza vaccine, human growth hormone-(177-191), human insulin; Indacaterol, INKP-100, INKP-102, insulin glargine, i.v. gamma-globulin; KLH; Lapatinib, L-arginine hydrochloride, lasofoxifene tartrate, levocetirizine, licochalcone A, LMI vaccine, lomefloxacin, lubiprostone, lumiracoxib; Miglustat, mycograb; Natalizumab, NCX-4016, nortopixantrone hydrochloride; Olmesartan medoxomil, omalizumab, oral insulin, OrM3; Parathyroid hormone (human recombinant), parecoxib sodium, PCK-3145, PEG-filgrastim, peginterferon alfa-2a, pemetrexed disodium, pexelizumab, photochlor, pimecrolimus, pneumococcal 7-valent conjugate vaccine, polyphenon E; R-126638, R-411, resveratrol, roflumilast, RS-86, ruboxistaurin mesilate hydrate, rupatadine fumarate; Sipuleucel-T, somatropin, St. John's Wort extract; Tadalafil, Taxus, telbivudine, telithromycin, temsirolimus, teriparatide, teverelix, tigecycline, tiotropium bromide, tolterodine, tolvaptan, treprostinil sodium, typhoid vaccine; Vardenafil hydrochloride hydrate, vildagliptin, voriconazole; Ximelagatran; Zanolimumab, zileuton."
4.	Hypersensitivity (Allergy) 01/01/2004 - "This is the first case of allergy to ALA-ME." 03/01/2008 - "Allergic reactions to Metvix (ALA-ME)." 01/01/2004 - "We report a patient with an allergy induced by photodynamic therapy (PDT) following simultaneous treatment with both 5-aminolaevulinic acid (ALA) and ALA methylester (ALA-ME). "
5.	Rheumatoid Arthritis 02/05/2013 - "Spectroscopic assessment of endogenous porphyrins in a rheumatoid arthritis rabbit model after the application of ALA and ALA-Me." 02/05/2013 - "Thus, in vivo and ex vivo spectroscopic assessment of endogenous porphyrins in rabbit rheumatoid arthritis tissues implied that the injection of ALA is more appropriate for the diagnostics of inflammation due to the higher PpIX fluorescence intensity on the skin surface, while ALA-Me is more appropriate for the therapeutic applications due to the higher and more selective accumulation of PpIX in the inflamed synovium." 12/01/2014 - "To compare the accumulation of protoporphyrin IX between synoviocytes of patients with rheumatoid arthritis (RA) or osteoarthritis (OA) and cartilage explants (CE) as well as chondrons of patients with OA after the application of 5-aminolevulinic acid (ALA) or its methyl ester (ALA-Me). "

Related Drugs and Biologics

1.	Acids
2.	Vaccines
3.	Sodium
4.	Bevacizumab (Avastin)
5.	Darbepoetin alfa (Aranesp)
6.	ciclesonide
7.	peginterferon alfa-2a (Pegasys)
8.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
9.	Salts
10.	Fumarates

Related Therapies and Procedures

1.	Stents
2.	Photochemotherapy (Photodynamic Therapy)
3.	Lasers (Laser)