|1.||Roffler, Steve R: 2 articles (01/2015 - 04/2009)|
|2.||Chen, Kai-Chuan: 2 articles (01/2015 - 04/2009)|
|3.||Hasegawa, Takaaki: 2 articles (01/2013 - 09/2011)|
|4.||Yoshida, Teruhiko: 2 articles (10/2007 - 06/2004)|
|5.||Jinno, Hideto: 2 articles (10/2007 - 06/2004)|
|6.||Shirao, Kuniaki: 2 articles (10/2007 - 06/2004)|
|7.||Sawada, Jun-ichi: 2 articles (10/2007 - 06/2004)|
|8.||Minami, Hironobu: 2 articles (10/2007 - 06/2004)|
|9.||Ohtsu, Atsushi: 2 articles (10/2007 - 06/2004)|
|10.||Kaniwa, Nahoko: 2 articles (10/2007 - 06/2004)|
06/01/2011 - "Furthermore, an adenoviral vector expressing membrane-tethered βG (Ad.βG) increased the sensitivity of cancer cells to SN-38G even at multiplicity of infections as low as 0.16, indicating bystander killing of non-transduced cancer cells. "
04/01/2009 - "Here, we tested the hypothesis that tumor-located hydrolysis of endogenously generated SN-38G can enhance the antitumor efficacy of CPT-11 therapy. "
01/01/2015 - "coli (lux/βG), could hydrolyze SN-38G to SN-38, increased the sensitivity of cultured tumor cells to SN-38G by about 100 fold and selectively accumulated in tumors. "
03/01/2013 - "Internal validation confirms the population pharmacokinetic model describe the time course of irinotecan, SN-38 and SN-38G plasma concentration and their associated variability in cancer patients. "
04/01/2009 - "Thus, the anticancer activity of CPT-11 can be significantly enhanced by converting the relatively high levels of endogenously generated SN-38G to SN-38 in tumors. "
|2.||Small Cell Lung Carcinoma (Small Cell Lung Cancer)
|3.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/01/2009 - "On the other hand, the ratio between the AUC of SN-38 and the AUC of SN-38G (AUCSN-38/AUCSN-38G) indicates the ability of SN-38 to be glucuronidated, and is known to correlate with leucopenia and diarrhea. "
09/01/2002 - "In this population analysis, irinotecan and SN-38G AUC values were appropriate predictors of the risk for diarrhea, and SN-38G AUC showed the stronger relationship of the two. "
09/01/2002 - "Significant correlations between AUC(0-60) and diarrhea scores were found for irinotecan (P <.05) and SN-38G (P <.01) but not for SN-38 or the biliary index. "
10/01/2008 - "SN-38G, once excreted in the intestinal lumen via bile, is extensively deconjugated by bacterial beta-glucuronidase with the regeneration of SN-38 in the intestinal lumen, which may cause diarrhea. "
07/01/2014 - "Bacteria β-glucuronidase (GUS) enzymes in intestines convert the nontoxic metabolite of CPT-11, SN-38G, to toxic SN-38, and finally lead to damage of intestinal epithelial cells and diarrhea. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
04/01/2014 - "We investigated the relationship between the SN-38G/SN-38 concentration ratio and the dose of CPT-11 in 70 patients with colorectal cancer who received FOLFIRI-based regimens, by measuring the plasma concentrations of CPT-11, SN-38, and SN-38G. "
05/01/1999 - "CPT-11, SN-38, and SN-38G area under the plasma concentration-time curves through infinite time values in these patients were approximately 40%, 25%, and 25%, respectively, of those determined previously in patients with metastatic colorectal cancer not receiving antiepileptics or chronic dexamethasone treatment. "
|8.||Anticonvulsants (Antiepileptic Drugs)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)