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4-phenyl-2-propionamidotetraline

melatonin receptor antagonist; structure in first source

Also Known As:

4P-PDOT

Networked: 9 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        4-phenyl-2-propionamidotetraline: 9
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - 4-phenyl-2-propionamidotetraline: 9

Experts

1.	Feng, Y: 1 article (01/2022)
2.	Hu, S: 1 article (01/2022)
3.	Jiang, H: 1 article (01/2022)
4.	Ke, J: 1 article (01/2022)
5.	Li, H: 1 article (01/2022)
6.	Liu, W: 1 article (01/2022)
7.	Liu, X: 1 article (01/2022)
8.	Long, X: 1 article (01/2022)
9.	Chang, Chi-Fen: 1 article (11/2020)
10.	Chen, Seu-Hwa: 1 article (11/2020)

Related Diseases

1.	Pain (Aches) 01/01/2015 - "Heat pain latency in PHN rats were lower than that of control group (P<0.05), MT could increase the heat pain latency with dose-dependent, while naloxone, 4P-PDOT and L-arginine could reverse the analgesic effect of MT (P<0.05). " 04/01/2016 - "Notably, intrathecal administration with MLT increased PP2Ac expression, HDAC4 dephosphorylation and nuclear accumulation, restored HDAC4-mediated hmgb1 suppression and relieved SNL-sensitized behavioral pain; these effects were all inhibited by spinal injection of 4P-PDOT (a MT2 receptor antagonist, 30 minutes before MLT) and okadaic acid (OA, a PP2A inhibitor, 3 hr after MLT). "
2.	Chronic Pain 01/01/2022 - "Nociceptive behavior as assessed by von Frey and the Rat Grimace Scale demonstrated that exogenous administration of MT relieved chronic pain in TMJOA rats, whereas blocking MT2R with 4P-PDOT reversed the analgesic effect of MT. "
3.	Stroke (Strokes) 05/01/2012 - "RT-PCR revealed that the gene expression levels of doublecortin, ki67, adamts20, and adam11 are markedly reduced by stroke, but are restored by melatonin treatment; furthermore, pretreatment with 4P-PDOT and luzindole antagonized melatonin's restorative effect. "
4.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 11/01/2023 - "Moreover, in a subset of rats with subarachnoid hemorrhage who received pre-treatment via intravenous injection of the melatonin receptor antagonist Luzindole (1 mg/kg) and 4P-PDOT (1 mg/kg), we found that the protective effect of melatonin against subarachnoid hemorrhage includes inhibition of lipid peroxidation and reduction of iron accumulation depended on melatonin receptor 1B (MT2). "
5.	Neoplasms (Cancer) 10/01/2003 - "The receptor subtype identity of melatonin receptor expressed in the cancer tissue was determined by comparison of the rank order of inhibition constants (Ki) of various melatonergic ligands and the affinity of 4-phenyl-2-propionamidotetraline relative to melatonin in inhibiting 2-[125I]iodomelatonin binding to the tumor sample and to human cell lines stably transfected with MT1 or MT2 melatonin receptor subtype. "

Related Drugs and Biologics

1.	MT2 Melatonin Receptor
2.	Analgesics (Analgesic Drugs)
3.	HMGB1 Protein (HMG1)
4.	Okadaic Acid
5.	Melatonin
6.	Melatonin Receptors (Melatonin Receptor)
7.	luzindole
8.	MT1 Melatonin Receptor
9.	Prazosin (Minipress)
10.	Naloxone (Narcan)

Related Therapies and Procedures

1.	Spinal Injections
2.	Intravenous Injections