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nitric oxide dioxygenase

catalyzes conversion of nitric oxide to nitrate in the presence of NADPH, FAD and oxygen; cyanide-sensitive; contains flavohemoglobin

Also Known As:

NO dioxygenase; NOD enzyme

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - nitric oxide dioxygenase: 10

Experts

1.	Bauer, Georg: 2 articles (03/2015 - 10/2014)
2.	Scheit, Katrin: 2 articles (03/2015 - 10/2014)
3.	Bidon-Chanal, Axel: 2 articles (05/2009 - 08/2006)
4.	Dikshit, Kanak L: 2 articles (05/2009 - 09/2002)
5.	Luque, F Javier: 2 articles (05/2009 - 08/2006)
6.	Abd-Allah, Adel R: 1 article (01/2022)
7.	El-Mahdy, Mohamed A: 1 article (01/2022)
8.	Khaleel, Sahar A: 1 article (01/2022)
9.	Mahgoup, Elsayed M: 1 article (01/2022)
10.	Zweier, Jay L: 1 article (01/2022)

Related Diseases

1.	Tuberculosis (Tuberculoses) 09/01/2002 - "tuberculosis exhibits distinct nitric oxide dioxygenase (NOD) activity and protects growth and cellular respiration of heterologous hosts, Escherichia coli and Mycobacterium smegmatis, from the toxic effect of exogenous NO and the NO-releasing compounds. " 05/22/2009 - "tuberculosis HbN drastically reduces its ability to scavenge nitric oxide (NO), whereas its insertion at the N terminus of Pre-A lacking HbN of Mycobacterium smegmatis improved its nitric-oxide dioxygenase activity. " 08/01/2006 - "tuberculosis has evolved a defense mechanism that relies on the oxygenated form of "truncated hemoglobin" N (trHbN), formally acting as NO-dioxygenase, yielding the harmless nitrate ion. "
2.	Neoplasms (Cancer) 03/01/2015 - "Here, we show that salicylic acid and anthocyanidins inactivate tumor cell protective catalase and thus reactive apoptosis-inducing intercellular reactive oxygen species signaling of tumor cells and the mitochondrial pathway of apoptosis Salicylic acid inhibits catalase directly through its potential to transform compound I of catalase into the inactive compound II. In contrast, anthocyanidins provoke a complex mechanism for catalase inactivation that is initiated by anthocyanidin-mediated inhibition of NO dioxygenase. " 10/01/2014 - "Inhibitors of catalase (such as ascorbate, methyldopa, salicylic acid and neutralizing antibodies) synergize with modulators of nitric oxide (NO) metabolism (such as arginine, arginase inhibitor, NO synthase-inducing interferons and NO dioxygenase inhibitors) in the singlet oxygen-mediated inactivation of tumor cell protective catalase. "
3.	Starvation 10/01/2016 - "Expression factor analysis revealed that the nitric oxide dioxygenase-coding gene was induced by nitric oxide and the five clustered genes were induced under phosphate starvation. "
4.	Poisoning 10/01/2008 - "It is therefore possible that SHP functions physiologically as a nitric oxide dioxygenase, protecting the organism against NO poisoning, and we propose a possible mechanism for this process."
5.	Infections 01/01/2021 - "To survive and establish a successful infection, a fulminating human pathogen Vibrio vulnificus expresses the hmpA gene encoding an NO dioxygenase in an NO-responsive manner. "

Related Drugs and Biologics

1.	Nitric Oxide (Nitrogen Monoxide)
2.	Salicylic Acid (2 Hydroxybenzoic Acid)
3.	Catalase
4.	Neutralizing Antibodies
5.	Truncated Hemoglobins
6.	Singlet Oxygen
7.	Nitric Oxide Synthase (NO Synthase)
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Phosphates (Orthophosphate)
10.	Nitrates