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ZD 0892

a trifluoromethyl ketone-based; structure in first source

Also Known As:

ZD-0892

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - ZD 0892: 3
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - ZD 0892: 3
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - ZD 0892: 3

Experts

1.	Fu, Li-jun: 1 article (05/2004)
2.	Li, Fen: 1 article (05/2004)
3.	Shen, Jie: 1 article (05/2004)
4.	Zhao, Wu: 1 article (05/2004)
5.	Zhou, Ai-qing: 1 article (05/2004)
6.	Ohbayashi, Hiroyuki: 1 article (07/2002)
7.	Ohbayashi, H: 1 article (10/2000)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/2000 - "ZD-0892, a neutrophil elastase inhibitor, is under development by AstraZeneca as a potential treatment for chronic obstructive pulmonary disease (COPD) and peripheral vascular disease (PVD). " 07/01/2002 - "In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-200,880, ZD-0892 and ZD-8321 as the transition-state inhibitors. "
2.	Peripheral Vascular Diseases (Peripheral Vascular Disease) 10/01/2000 - "ZD-0892, a neutrophil elastase inhibitor, is under development by AstraZeneca as a potential treatment for chronic obstructive pulmonary disease (COPD) and peripheral vascular disease (PVD). "
3.	Pulmonary Hypertension 05/01/2004 - "ZD-0892 can suppress the elastase activity and completely reverse the fatal pulmonary hypertension induced by monocrotaline in rats."

Related Drugs and Biologics

1.	Secretory Proteinase Inhibitory Proteins
2.	Monocrotaline
3.	Pancreatic Elastase (Elastase)
4.	Enzyme Inhibitors (Inhibitors, Enzyme)
5.	N- ((3- (carboxymethyl)- 2- oxoimidazolidin- 1- yl)acetyl)- l- valyl- N- ((3S)- 1,1,1- trifluoro- 4- methyl- 2- oxopentan- 3- yl)- l- prolinamide
6.	ONO 6818
7.	TEI 8362
8.	ZD 8321
9.	DMP 777
10.	MDL 201,404YA

Related Therapies and Procedures

1.	Therapeutics