Tissue Plasminogen Activator FDA Link

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

Also Known As:

Alteplase; Activase; T-Plasminogen Activator; Actilyse; Lysatec rt-PA; TTPA; Tisokinase; Tissue Activator D-44; Lysatec rt PA; Lysatec rtPA; Plasminogen Activator, Tissue; Plasminogen Activator, Tissue Type; T Plasminogen Activator; Tissue Activator D 44; Tissue Type Plasminogen Activator; Plasminogen Activator, Tissue-Type; Tissue-Type Plasminogen Activator

Pharmalogical Action Categories:

Fibrinolytic Agents

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Tissue Plasminogen Activator: 10595
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Tissue Plasminogen Activator: 10595
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Plasminogen Activators: 5174
        Tissue Plasminogen Activator: 10595
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - Tissue Plasminogen Activator: 10595

1.	Venous Thrombosis (Deep-Vein Thrombosis) 12/13/1998 - "Thrombolytic effect after sequential double-bolus administration of tissue plasminogen activator and urokinase-fibrinogen conjugate into dogs with venous thrombosis."

urokinase-fibrinogen conjugate

Bio-Agent Context: Research Results

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