1-deoxy-D-xylulose 5-phosphate reductoisomerase

catalyzes conversion of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate in the presence of NAD(P)H and a divalent ion such as Mn(II) or Co(II)

Also Known As:

2C-methyl-D-erythritol 4-phosphate synthase; DOXP reductoisomerase; DXP reductoisomerase; deoxyxylulose 5-phosphate reductoisomerase; ispC protein, E coli; yaeM protein, E coli

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Oxidoreductases
      - Aldose-Ketose Isomerases
        1-deoxy-D-xylulose 5-phosphate reductoisomerase: 5

Experts

1.	Azam, Syed Sikandar: 1 article (12/2017)
2.	Ghufran, Mehreen: 1 article (12/2017)
3.	Hassan, Syed Fahad: 1 article (12/2017)
4.	Khan, Huma: 1 article (12/2017)
5.	Rashid, Umer: 1 article (12/2017)
6.	Wadood, Abdul: 1 article (12/2017)
7.	Cui, Lijie: 1 article (09/2014)
8.	Hao, Xiaolong: 1 article (09/2014)
9.	Huang, Qiang: 1 article (09/2014)
10.	Ju, Guanhua: 1 article (09/2014)

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria) 12/01/2017 - "In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria." 01/01/2011 - "falciparum malaria by inhibiting 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an enzyme of the non-mevalonate pathway, which is absent in humans. "
2.	Malaria 01/01/2007 - "The most over-represented classes of compounds in malaria patent literature in order of frequency are artemisinin analogs, quinoline derivatives, DOXP reductoisomerase inhibitors, antifolates and febrifugine analogues. "
3.	Cerebrovascular Disorders (Cerebrovascular Occlusion) 09/01/2014 - "Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase."
4.	Bacterial Infections (Bacterial Infection) 06/01/2003 - "Fosmidomycin, a natural antibiotic originally developed for the treatment of bacterial infections, represents an inhibitor of DOXP reductoisomerase, an essential enzyme of this pathway. "

Related Drugs and Biologics

1.	Enzymes
2.	Mevalonic Acid (Mevalonate)
3.	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
4.	Folic Acid Antagonists
5.	Anti-Bacterial Agents (Antibiotics)
6.	quinoline
7.	artemisinin (artemisinine)
8.	fosmidomycin
9.	tanshinone
10.	febrifugine