|1.||Heber, David: 8 articles (08/2006 - 09/2002)|
|2.||Ikezoe, Takayuki: 7 articles (09/2007 - 09/2002)|
|3.||Koeffler, H Phillip: 7 articles (09/2007 - 09/2002)|
|4.||Taguchi, Hirokuni: 6 articles (09/2007 - 10/2003)|
|5.||Oh, William K: 5 articles (09/2004 - 02/2002)|
|6.||Montgomery, Bruce: 4 articles (03/2008 - 07/2002)|
|7.||Yang, Yang: 4 articles (09/2007 - 11/2003)|
|8.||Small, Eric J: 4 articles (09/2005 - 02/2002)|
|9.||Nelson, Peter S: 3 articles (05/2005 - 07/2002)|
|10.||Sadava, David: 3 articles (04/2005 - 04/2002)|
|1.||Prostatic Neoplasms (Prostate Cancer)
02/27/2003 - "Here we use PC-SPES, a combination of eight herbs that has been shown to be effective in clinical trials in patients with prostate cancer, as a model system to demonstrate 'proof of principle' as to how gene expression profiling coupled with promoter assays can evaluate the effect of herbal cocktails on human prostate cancer. "
07/01/2002 - "Previous studies have suggested that the clinical efficacy of PC-SPES, a dietary supplement used frequently by men diagnosed with androgen-dependent (AD) or androgen-independent (AI) prostate cancer (CaP), is mechanistically attributed to estrogenic components present in the herbal mixture. "
01/01/2003 - "PC-SPES is an herbal mixture, with evidence of clinical efficacy against prostate cancer (CaP), recently attracting tremendous attention. "
05/15/2005 - "Scutellaria baicalensis, a botanical with a long history of medicinal use in China, was a constituent of the herbal mixture PC-SPES, a product that inhibited prostate cancer growth in both laboratory and clinical studies. "
11/01/2003 - "We conducted this study to begin to clarify the molecular mechanism by which PC-SPES inhibited the growth of prostate cancer cells and down-regulated expression of PSA. "
08/01/2001 - "Concurrent animal studies using 2 different models, Copenhagen rats and nude mice, confirmed a dose-dependent suppressive effect of PC SPES on tumor volumes and tumor progression. "
05/01/2009 - "PC-Spes is a preparation of eight Chinese herbs, which exhibits antiproliferative and antitumour activity in diverse cancer types in vivo and in vitro. "
08/01/2006 - "PC-SPES might be useful in the adjuvant setting for the treatment of individuals with resected NSCLC as well as other types of cancer in which COX-2 is activated."
11/06/2002 - "Several herbal constituents in PC-SPES inhibit tumor growth through cell cycle arrest and apoptosis, although the mechanisms of these activities are poorly defined. "
09/15/2002 - "The Apc(min) mice given PC-SPES had a 58% reduction in tumor number and a 56% decrease in tumor load. "
02/01/2013 - "Previously, a growth inhibiting effect of PC-Spes on head and neck carcinoma cell lines had been demonstrated. "
06/01/2007 - "[Chinese herbal medicine PC-SPES II induces the apoptosis of androgen-independent prostate carcinoma cell line PC-3]."
04/08/2005 - "In contrast to the data reported for prostate carcinoma cells, extracts of batches of PC-SPES from the year 1998 (reportedly contaminated) and 2001 (much less contaminated) were equally cytotoxic in both SCLC cell lines. "
11/06/2002 - "PC-SPES is a botanical preparation shown to have efficacy in patients with androgen-dependent and androgen-independent prostate carcinoma. "
07/15/2002 - "Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma."
|5.||Breast Neoplasms (Breast Cancer)
01/01/2005 - "In this study, we examined the inhibitory effects of certain individual components of PC-SPES on the in vitro proliferation of the human breast cancer cells MDA-MB231 and the human umbilical vein endothelial cells (HUVEC). "
09/04/2002 - "Antineoplastic activity of PC-SPES and its individual component extracts was determined by colony-forming assays with several prostate cancer cell lines, and estrogenicity was determined by analyzing expression of an estrogen-responsive reporter gene in breast cancer cells. "
|1.||NF-kappa B (NF-kB)
|7.||Prostate-Specific Antigen (Semenogelase)
|9.||Complementary DNA (cDNA)
|10.||Androgen Receptors (Androgen Receptor)
|1.||Phytotherapy (Herbal Therapy)
|3.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Prostatectomy (Retropubic Prostatectomy)