herbal preparation PC-SPES

a commercially available herbal combination containing 8 herbs: chrysanthemum, isatis, licorice, Ganoderma lucidum, Panax pseudo-ginseng, Robdosia rubescens, saw palmetto & scutellaria (skullcap); used for the treatement of prostate cancer

Also Known As:

Networked: 86 relevant articles (2 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Heber, David: 8 articles (08/2006 - 09/2002)
2.	Ikezoe, Takayuki: 7 articles (09/2007 - 09/2002)
3.	Koeffler, H Phillip: 7 articles (09/2007 - 09/2002)
4.	Taguchi, Hirokuni: 6 articles (09/2007 - 10/2003)
5.	Oh, William K: 5 articles (09/2004 - 02/2002)
6.	Montgomery, Bruce: 4 articles (03/2008 - 07/2002)
7.	Yang, Yang: 4 articles (09/2007 - 11/2003)
8.	Small, Eric J: 4 articles (09/2005 - 02/2002)
9.	Nelson, Peter S: 3 articles (05/2005 - 07/2002)
10.	Sadava, David: 3 articles (04/2005 - 04/2002)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 02/27/2003 - "Here we use PC-SPES, a combination of eight herbs that has been shown to be effective in clinical trials in patients with prostate cancer, as a model system to demonstrate 'proof of principle' as to how gene expression profiling coupled with promoter assays can evaluate the effect of herbal cocktails on human prostate cancer. " 05/15/2005 - "Scutellaria baicalensis, a botanical with a long history of medicinal use in China, was a constituent of the herbal mixture PC-SPES, a product that inhibited prostate cancer growth in both laboratory and clinical studies. " 11/01/2003 - "We conducted this study to begin to clarify the molecular mechanism by which PC-SPES inhibited the growth of prostate cancer cells and down-regulated expression of PSA. " 02/27/2003 - "Since prior studies have shown that PC-SPES contains estrogenic organic compounds, and such compounds are known to affect prostate cancer, an important issue is whether these are the primary drivers of the gene profile. " 09/04/2002 - "The herbal mixture PC-SPES, used to manage advanced prostate cancer, has proven thrombogenic and highly estrogenic in clinical trials. "
2.	Sepsis (Septicemia) 12/01/2003 - "Together, PC-SPES is a potent inhibitor of NF-kappaB and might be useful for the treatment of sepsis and inflammatory diseases."
3.	Neoplasms (Cancer) 08/01/2001 - "Concurrent animal studies using 2 different models, Copenhagen rats and nude mice, confirmed a dose-dependent suppressive effect of PC SPES on tumor volumes and tumor progression. " 05/01/2021 - "Licorice root has cancer chemopreventive effects and has been given to PCa patients as an ingredient of PC-SPES, a commercially available combination of eight herbs. " 05/01/2009 - "PC-Spes is a preparation of eight Chinese herbs, which exhibits antiproliferative and antitumour activity in diverse cancer types in vivo and in vitro. " 08/01/2006 - "PC-SPES might be useful in the adjuvant setting for the treatment of individuals with resected NSCLC as well as other types of cancer in which COX-2 is activated." 11/06/2002 - "Several herbal constituents in PC-SPES inhibit tumor growth through cell cycle arrest and apoptosis, although the mechanisms of these activities are poorly defined. "
4.	Carcinoma (Carcinomatosis) 02/01/2013 - "Previously, a growth inhibiting effect of PC-Spes on head and neck carcinoma cell lines had been demonstrated. " 04/08/2005 - "In contrast to the data reported for prostate carcinoma cells, extracts of batches of PC-SPES from the year 1998 (reportedly contaminated) and 2001 (much less contaminated) were equally cytotoxic in both SCLC cell lines. " 07/15/2002 - "Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma." 04/01/2001 - "[Progress in research on PC-SPES anti-cancer agents in prostatic carcinoma in USA]." 06/01/2007 - "[Chinese herbal medicine PC-SPES II induces the apoptosis of androgen-independent prostate carcinoma cell line PC-3]."
5.	Breast Neoplasms (Breast Cancer) 01/01/2005 - "In this study, we examined the inhibitory effects of certain individual components of PC-SPES on the in vitro proliferation of the human breast cancer cells MDA-MB231 and the human umbilical vein endothelial cells (HUVEC). " 09/04/2002 - "Antineoplastic activity of PC-SPES and its individual component extracts was determined by colony-forming assays with several prostate cancer cell lines, and estrogenicity was determined by analyzing expression of an estrogen-responsive reporter gene in breast cancer cells. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Androgens
3.	Diethylstilbestrol (Stilbestrol)
4.	Hormones (Hormone)
5.	Prostate-Specific Antigen (Semenogelase)
6.	Estrogens (Estrogen)
7.	Complementary DNA (cDNA)
8.	Androgen Receptors (Androgen Receptor)
9.	Cyclins
10.	Antigens

Related Therapies and Procedures

1.	Therapeutics
2.	Phytotherapy (Herbal Therapy)
3.	Aftercare (After-Treatment)
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Prostatectomy (Retropubic Prostatectomy)