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T 241

neuropeptide Y Y1 receptor antagonist

Also Known As:

(Trp-Arg-Nva-Arg-Tyr)2-NH2; T-241; tryptophyl-arginyl-norvalyl-arginyl-tyrosyl-tryptophyl-arginyl-norvalyl-arginyl-tyrosinamide

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - T 241: 6

Experts

1.	Baban, Dilair: 1 article (09/2008)
2.	Butz, Stefan: 1 article (09/2008)
3.	Cao, Yihai: 1 article (09/2008)
4.	Clasper, Steven: 1 article (09/2008)
5.	Ewers, Stephan: 1 article (09/2008)
6.	Jackson, David G: 1 article (09/2008)
7.	Royston, Daniel: 1 article (09/2008)
8.	Vestweber, Dietmar: 1 article (09/2008)
9.	Avol, Edward: 1 article (09/2005)
10.	Conti, David V: 1 article (09/2005)

Related Diseases

1.	Asthma (Bronchial Asthma) 09/01/2005 - "We investigated the role of intercellular adhesion molecule-1 in childhood asthma by examining associations of functional variants at codons 29 (A --> T), 241 (G --> A), and 469 (A --> G) in Children's Health Study participants. "
2.	Fibrosarcoma 07/01/1983 - "Production of immunosuppressive factor(s) by a weakly immunogenic fibrosarcoma T 241." 03/01/1984 - "Lysate from T-241 murine fibrosarcoma cells contains a low-molecular-weight (Mr less than 1000), heat-stable peptide factor which has antichemotactic activity for both macrophages and polymorphonuclear leukocytes in vitro. " 09/15/2008 - "Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. "
3.	Sarcoma (Soft Tissue Sarcoma) 11/01/1952 - "In tissue cultures of C-57 black mouse heart and sarcoma T-241, beta-2-thienyl-DL-alanine acts specifically as a phenylalanine antagonist. " 11/01/1952 - "Heart cultures can transaminate between beta-2-thienyl-DL-alanine and phenylpyruvate to form L-phenylalanine and thus block the toxic action of the remaining beta-2-thienyl-DL-alanine, whereas sarcoma T-241 cultures cannot. "
4.	Acute Erythroblastic Leukemia (Erythroleukemia) 05/15/1998 - "Because BW1911U90, T-190 and T-241 are significantly less potent at the cloned human neuropeptide Y Y1 receptor than at the neuropeptide Y receptor in human erythroleukemia cells, these cells may express a novel neuropeptide Y receptor with high affinity for these peptides."

Related Drugs and Biologics

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	Codon (Codons)
3.	Peptides (Polypeptides)
4.	Vascular Endothelial Growth Factor C
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Neuropeptide Y Receptors (Neuropeptide Y Receptor)
7.	RNA (Ribonucleic Acid)
8.	Phenylalanine (L-Phenylalanine)
9.	Neuropeptide Y
10.	Toxic Actions